Results 91 to 100 of about 599,601 (278)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Physician assistant/associate career flexibility: factors associated with specialty transitions

BMC Health Services Research
Background Physician assistants/associates (PAs), due to their broad medical education and certification, have the flexibility to change specialties throughout their careers. Prior studies suggest that between half and three-quarters exercise this option
Andrzej Kozikowski, Mirela Bruza-Augatis, Dawn Morton-Rias, Kasey Puckett, Colette Jeffery, James F. Cawley, Roderick S. Hooker, Alicia Quella, Sheila Mauldin, Joshua Goodman   +9 more
doaj   +1 more source

Perceived Barriers and Facilitators to the use of Point-of-Care Ultrasound for Clinicians in Oregon

POCUS Journal, 2019
The use of Point-of-Care Ultrasound (POCUS) to provide clinical data beyond the history and physical examination is a relatively new practice for primary care providers and hospitalists.
Camellia Dalai, Renee K. Dversdal
doaj   +1 more source

The Associate ; March 2012.

, 2012
Undergraduate student newspaper covering issues of business, entrepreneurship, marketing and finance."The Associate is Syms School of Business' first (and only) student-run publications.
Harris, Yoni
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Examining attitudes of specialist physicians regarding physician assistant referrals

, 2003
Click on the link below to access the article( may not be free)Referral of a patient from a primary care provider to a referral specialist physician for consultation is an important link in the continuum of patient care. Although the relationship between
Muma, Richard D., Lary, Marvis J., Enns, Sue M., Wynn, Tor   +3 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Associate ; January 2012.

, 2012
Student newspaper of Syms School of Business."The Associate is Syms School of Business; first (and only) student-run publication. It aims to provide unique and interesting business related news to the SYMS and YU student bodies. The Associate prides
Syms School of Business
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluating the impact of introducing Physician Associates to cancer units of urology, breast surgery and colorectal surgery – Experiences from the Wessex Cancer Alliance, UK

Journal of Healthcare Administration
Background: The National Health Service (NHS) faces a crisis in managing cancer patients in a timely manner. One proposed solution to this problem is through workforce expansion and diversification of professionals capable of treating patients. Physician
Susanne Theis, Hayley Hart
doaj   +1 more source