Results 91 to 100 of about 82,870 (241)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Recurrent fever in a patient with hereditary spherocytosis: A case report
مجله دانشگاه علوم پزشکی گرگان, 2014 Borreliosis or recurrent fever is a spirochete disease which is caused by various species of borrelia and characterized by recurrent episodes of fever, chills and spirochetemia that could lead to multiple organ involvement and even death.
Khodabakhshi B +2 more
doaj
Physician associate prescribing: perspectives, practices and pathways. [PDF]
Future Healthc J, 2022 Guest BN +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
PA-rticipating in simulation: developing a novel teaching programme mapped to the physician associate curriculum, using simulation and interactive workshops to cover core conditions and non-technical skills. [PDF]
Future Healthc J, 2023 Zucca N, Higgie E, Parker H.
europepmc +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
The development of a bespoke Physician Associate teaching programme and CPD framework
Future Healthcare JournalBackground: Following successful completion of the Physician Associate (PA) National Examination, all qualified PAs must complete and log a minimum of fifty hours of continuous professional development (CPD) per annum via the Royal College of Physicians ...
Sian Harkin +2 more
doaj +1 more source
Developing and evaluating an instrument to assess perceptions of an entry-level physician associate doctoral degree. [PDF]
BMC Med Educ, 2022 Jun HJ +5 more
europepmc +1 more source