Results 71 to 80 of about 599,601 (278)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Examining attitudes of referral specialist physicians regarding physician assistant referrals

open access: yes, 2002
The nature of the relationship between the primary care PA and the specialist physician has not been well studied. It is apparent that although the majority of specialist physicians accept referrals from PAs and are accepting of the role of primary ...
Muma, Richard D.   +2 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Physician-leaders and hospital performance: Is there an association? [PDF]

open access: yesSocial Science & Medicine, 2011
Although it has long been conjectured that having physicians in leadership positions is valuable for hospital performance, there is no published empirical work on the hypothesis. This cross-sectional study reports the first evidence. Data were collected on the top-100 U.S.
openaire   +5 more sources

The ability of PAs to solve patients' psychosocial problems. A preliminary report on patient expectations

open access: yes, 1990
The full text of this article is not available in SOAR.Patient expectations of physician assistants constitute a relatively unexplored field. A survey was designed to evaluate the expectations that patients have of PAs faced with a patient's psychosocial
Elizondo, E., Blessing, J.D.
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Medical student reporting of factors affecting pre-clerkship changes in empathy: a qualitative study

open access: yesCanadian Medical Education Journal, 2013
Objective: To isolate factors that medical students identify as possibly affecting empathy in pre-clerkship years of medical school. Methods: 12 students in their second year of medical school at Queen’s University were randomly selected and asked to ...
Hasan Sheikh   +2 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

1993 Touro College Physician Assistant Program Yearbook [PDF]

open access: yes, 1993
1993 Touro College Physician Assistant Program Yearbookhttps://touroscholar.touro.edu/archives_books/1029/thumbnail ...
Touro College Physician Assistant Program
core   +1 more source

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