Results 61 to 70 of about 4,401,533 (312)
Family and Physicians' Views of Surrogate Decision-Making: The Roles and How to Choose
, 1996 Physicians and family members were compared on the roles played in surrogate decision-making and their views as to how choices should be made by surrogate decision-makers.
Silberfeld, Michel +3 more
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Sleep Duration and Obesity among Adults Under 65 Years of Age and the Elderly in Taiwan
International Journal of Gerontology, 2012 Background: This study investigated the determinants of obesity in adults younger than 65 years of age and those older than 65 years, focusing on the relationship between sleep duration and obesity after controlling other factors.
Meng-Ting Tsou
doaj +1 more source
Comprehensiveness of care by family physicians in Edmonton
, 2011 Andrew J Cave¹, Lakshmi Parameswaran²¹Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada; ²Mater Misericordiae University Hospital, Dublin, IrelandIntroduction: The scope of practice by ...
Parameswaran L, Cave AJ
core
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
The diabetic foot risks profile in Selebi Phikwe Government Hospital, Botswana
African Journal of Primary Health Care & Family Medicine, 2014 Aim: The present study aimed: (1) to evaluate the proportion of each diabetic foot (DF) risk category, according to the International Working Group on the Diabetic Foot (IWGDF) consensus, in patients attending the diabetic clinic in Selebi Phikwe ...
Stephane Tshitenge +3 more
doaj
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Медицинский совет, 2018 The flexible dosage form combined with the increased maintenance of a therapeutic dextensoprazole concentration in plasma with a modified release and prolonged inhibition of acid secretion after administration of the drug suggests that dexlansoprozole ...
N. V. Topchiy, A. S. Toporkov
doaj +1 more source
Family Physicians Managing Medical Requests From Family and Friends
, 2018 PURPOSE Although guidelines generally state that physicians should not treat their family members or friends (nonpatients), physicians regularly receive medical requests from nonpatients.
Jean W.M. Muris +11 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source