Results 61 to 70 of about 478,628 (315)

Umbilical cord blood: a guide for primary care physicians.

, 2022
Umbilical cord blood stem cell transplants are used to treat a variety of oncologic, genetic, hematologic, and immunodeficiency disorders. Physicians have an important role in educating, counseling, and offering umbilical cord blood donation and storage ...
Hesse, Brett, Martin, Paul L, Kurtzberg, Joanne   +2 more
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Misconceptions about Antibiotics in general practice

South African Family Practice, 1985
No abstract available.
Johan Dippenaar
doaj   +1 more source

“Better than having no evaluation done”: a pilot project to conduct remote asylum evaluations for clients in a migrant encampment in Mexico

BMC Health Services Research, 2021
Background Asylum evaluations are highly specialized medico-legal encounters to collect physical or mental health evidence for use in immigration proceedings.
Ranit Mishori, Kathryn Hampton, Hajar Habbach, Elsa Raker, Anjali Niyogi, Dona Murphey   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Health budget cuts will be paid for by the most vulnerable

South African Family Practice
No abstract available.
Jenny Nash, Andrew J. Ross, Mergan Naidoo, Tasleem Ras, Hanneke Brits, Sheena Mathew   +5 more
doaj   +1 more source

Some actual trends in Medical Education

Red U, 2012
Sincethe "Flexneriane" revolution 100 years ago, many attempts have been made to change how medicine is taught, and many new general tendencies in education have appeared.
Carlos Alberto Brailovsky, Ángel M Centeno   +1 more
doaj   +1 more source

Building Capacity in Family Medicine in Low and Middle Income Countries : An International Strategic Consultation Meeting of The Sadok Besrour Centre for Innovation in Global Health, November 9 - 11, 2012, Kingbridge Centre, Ontario, Canada; final report [PDF]

, 2013
Attendees solidified the vision, mission, and values of The Besrour Centre for Innovation in Global Health (part of the College of Family Physicians of Canada) as well as outlining five strategic directions that would mark the success of The Centre ...
College of Family Physicians of Canada. Research and Education Foundation
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source