Results 81 to 90 of about 1,000,658 (304)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The strategy for choosing a new-generation proton pump inhibitor dexlansoprazole in the treatment of gastroesophageal reflux disease

Медицинский совет, 2018
The flexible dosage form combined with the increased maintenance of a therapeutic dextensoprazole concentration in plasma with a modified release and prolonged inhibition of acid secretion after administration of the drug suggests that dexlansoprozole ...
N. V. Topchiy, A. S. Toporkov
doaj   +1 more source

Basic communicating and counselling skills for family physicians [PDF]

, 2005
Family physicians often encounter psychological problems in patients under their care. Treating these problems is integral to a holistic conception of primary healthcare.
Ho, DYF, Ho, RTH, Ng, SM, Wang, OHL
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Review of the Book \u3ci\u3eThe Cost of Talent: How Executives and Professionals are Paid and How it Affects America\u3c/i\u3e [PDF]

, 1995
[Excerpt] Why should the former President of Harvard University be concerned that during the 1970s and 1980s the earnings of doctors, lawyers in private practice, and top corporate executives grew substantially relative to the earnings of professors ...
Ehrenberg, Ronald G
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Implementation of data management and effect on chronic disease coding in a primary care organisation: A parallel cohort observational study

Journal of Innovation in Health Informatics, 2016
Background Consistent and standardized coding for chronic conditions is associated with better care; however, coding may currently be limited in electronic medical records (EMRs) used in Canadian primary care.
Michelle Greiver, Kimberly Wintemute, Babak Aliarzadeh, Ken Martin, Shahriar Khan, Dave Jackson, Jannet Leggett, Anita Lambert-Lanning, Maggie Siu   +8 more
doaj   +1 more source

Assessment of Knowledge, Comfort, and Skills Working with Transgender Clients of Saskatchewan Family Physicians, Family Medicine Residents, and Nurse Practitioners. [PDF]

Transgend Health, 2022
Christopherson L, McLaren K, Schramm L, Holinaty C, Ruddy G, Boughner E, Clay A, McCarron M, Clark M.   +8 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Sociocultural Factors That Potentially Affect the Institution of Prevention and Treatment Strategies for Hepatitis B in Chinese Canadians

Canadian Journal of Gastroenterology, 2009
BACKGROUND: Despite the availability of screening for chronic hepatitis B (CHB) infection and effective treatments now available, many at-risk individuals fail to seek appropriate medical attention.
Harry Wu, Colina Yim, Alex Chan, Michael Ho, Jenny Heathcote   +4 more
doaj   +1 more source