Results 101 to 110 of about 1,000,658 (304)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Developing a national clinical competency committee for family medicine training, South Africa

Journal of the Colleges of Medicine of South Africa
Entrustable professional activities (EPAs) have been introduced into family medicine training programmes across South Africa (SA) as part of a competency-based medical education (CBME) framework.
Louis S. Jenkins, Mergan Naidoo, Kefilwe Hlabyago, Dirk T. Hagemeister, Neetha Erumeda, Busisiwe Cawe, Tasleem Ras, Mulimisi Ramavhuya, Owen Eales   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Family physicians\u27 professional identity formation: a study protocol to explore impression management processes in institutional academic contexts. [PDF]

, 2014
BACKGROUND: Despite significant differences in terms of medical training and health care context, the phenomenon of medical students\u27 declining interest in family medicine has been well documented in North America and in many other developed countries
AA Armenakis, AA Mohamed, AM Pettigrew, AS Wharton, Australian Medical Association, B Buddeberg-Fischer, BL Beagan, C Hardy, C Hardy, C Pearce, C Rodríguez, C Rodríguez, Charo Rodríguez, CJ Fombrun, CM Fiol, D Muzzio, D Ravasi, DA Gioia, DB Bromley, E Goffman, EE Jones, EE Jones, Emmanuelle Bélanger, EW Morrison, Francois-Xavier Schweyer, G Cheney, H Ibarra, H Ibarra, H Leblebici, HK Walker, HS Becker, I Bowler, I Hodder, Inmaculada Pereiró-Berenguer, J Apker, J Evett, J Holmes, J Jordan, J Lester, Jane Burns, JE Dutton, JH Senf, JL Denis, JS Fernández-Ruiz, JW Meyer, JW Meyer, KD Elsbach, KH Pitkala, L Heracleous, L Heracleous, L Lingard, LA Wood, Laure Fiquet, LG Zucker, LL Putnam, LM Harter, LM Roberts, M Alvesson, M Cooke, M Kraatz, M Shapiro, M Snyder, Maria Ángeles Pastor-Mira, MB Brewer, MC Bolino, MD Beaulieu, ME Whitcomb, MJ Hatch, MQ Patton, MR Leary, N Phillips, P Rabany, P Sullivan, PA Pugno, PA Pugno, Pierre-Paul Tellier, PJ DiMaggio, PM Fandt, PS Tolbert, R Collier, R Greenwood, R Greenwood, R Suddaby, R Suddaby, R Suddaby, RA Krueger, RC Rist, RE Stake, RE Stake, RF Baumeister, RK Merton, RL Cruess, S Ainsworth, S Ainsworth, S Albert, S Kvale, S Lewin, S López-Roig, S Maguire, S Sarangi, S Schroeder, Sandrine Hugé, Sarah Spencer, SE Green, SJ Wayne, SM Nkomo, Sofia López-Roig, TA Judge, TA van Dijk, TB Lawrence, Teresa Pawlikowska, TM Brown, W Powell, WJ Orlikowski, WL Gardner, WM Sullivan, WR Scott, WR Scott, WR Scott, ZI Barsness   +119 more
core   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Prenatal Lead Exposure Risk Assessment by Vermont Maternity Care Providers [PDF]

, 2017
Introduction. One percent of women of childbearing age in the U.S. have blood lead levels ≥ 5 ug/dL, which are associated with maternal hypertension during pregnancy, neural tube and cardiac defects in infants, low birth weight, prematurity, and ...
Berkman, Amy M, Bradstreet, Matthew, Davis, Wendy, Johnston, Margaret S, Kinsley, Brendon, Leu, Rose Kristine, Patel, Niketu P, Sakradse, Maia, Zhang, George   +8 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sodium phosphate solution as bowel preparation for outpatient diagnostic and therapeutic manipulations

Амбулаторная хирургия, 2017
The article presents the main indications for bowel examination and data on the qualitative preparation of patients for the early diagnostics of malignant neoplasms and inflammatory bowel diseases.
N. V. Topchy, A. S. Toporkov
doaj  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Supporting general medicine residents in Japan: From the perspective of Japanese Association of Family Physicians Trainees, official committee of JPCA

Journal of General and Family Medicine, 2023
Yuki Otsuka, Shun Yashima, Keiichiro Ito, Gemmei Iizuka   +3 more
doaj   +1 more source