Results 81 to 90 of about 1,473,116 (296)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An Obligation to Provide Abortion Services: What Happens When Physicians Refuse? [PDF]

, 1996
Access to abortion services in the United States continues to decline. It does so not because of significant changes in legislation or court rulings but because fewer and fewer physicians wish to perform abortions and because most states now have ...
Woods, Robert D., Meyers, Christopher
core   +1 more source

Additional file 1: of A survey of Ethiopian physiciansâ experiences of bedside rationing: extensive resource scarcity, tough decisions and adverse consequences

, 2015
Questionaire used in the study "Values at the bedside Ethiopia".(PDF 559 kb)
Frehiwot Defaye, Dawit Desalegn, Danis, Marion, Hurst, Samia, Yemane Berhane, Norheim, Ole, Miljeteig, Ingrid   +6 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

How Payment Systems Affect Physicians' Provision Behaviour – An Experimental Investigation [PDF]

Understanding how physicians respond to incentives from payment schemes is a central concern in health economics research. We introduce a controlled laboratory experiment to analyse the influence of incentives from fee-for-service and capitation payments
Reinhard Selten, Heike Hennig-Schmidt, Daniel Wiesen   +2 more
core  

A panel data study of physicians’ labor supply: The case of Norway [PDF]

Physicians are key personnel in a sector which is important due to its size as well as the quality of service it provides. We estimate the labor supply of physicians employed at hospitals in Norway, using personnel register data merged with other public ...
Holmås, Tor Helge, Bratberg, Espen, Baltagi, Badi H.   +2 more
core   +3 more sources

Additional file 1: Appendix 1. of Diagnostic validity and triage concordance of a physiotherapist compared to physiciansâ diagnoses for common knee disorders

, 2017
Flowchart of patients recruitment. (DOCX 59 kb)
S. DĂŠcary, M. Fallaha, B. Pelletier, P. FrĂŠmont, J. Martel-Pelletier, J.-P. Pelletier, D. Feldman, M.-P. Sylvestre, P.-A. Vendittoli, F. Desmeules   +9 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Additional file 2: of Understanding nursesâ and physiciansâ fear of repercussions for reporting errors: clinician characteristics, organization demographics, or leadership factors?

, 2015
Bivariate analyses for fear scale. (DOCX 21 kb)
Castel, Evan, Ginsburg, Liane, Zaheer, Shahram, Tamim, Hala   +3 more
openaire   +1 more source