Results 111 to 120 of about 2,165,213 (344)
THE PHYSICIAN AND PROHIBITION [PDF]
Journal of the American Medical Association, 1920 The question now before us is not whether prohibition of the use of intoxicating liquors as beverages is right or wrong—though most of us are convinced that it is one of the most beneficent acts ever passed by a legislature—but, it being the law of the land, how we can aid in its enforcement not merely passively, by obeying the rules and regulations ...
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
The Goulstonian Lectures on the Chemistry and Pathology of Gout: Delivered before the Royal College of Physicians, March, 1897 [PDF]
, 1897 A. P. Luff
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Journal of the American College of Cardiology, 2003 The thought began to germinate during the past Christmas holidays. It may have been the religious connotation, the gathering of family, or just the general “peace on earth” sense of the season that created a contemplative mood.
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
The Mitchell Lecture ON TUBERCULOSIS OF THE LARYNX: ITS SIGNIFICANCE TO THE PHYSICIAN: Deliverd before the Royal College of Physicians of London, November 6th, 1924 [PDF]
, 1924 Simon Thomson
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Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
PHYSICAL CHEMISTRY FOR PHYSICIANS AND BIOLOGISTS. [PDF]
, 1903 F. G. Cottrell
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