In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Science Writers, Physicians, and the Public -- Menage a Trois [PDF]
Page, Irvine H.
core +1 more source
Comparison of emergency physicians and artificial intelligence models in pneumothorax detection: A multi-reader retrospective study. [PDF]
Cakiroglu OF +7 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Hospital System Acquisition of Physician Practices.
Young GJ +4 more
europepmc +1 more source
Ethical perceptions of DRG-based hospital financing among physicians and hospital managers in Germany: a cross-sectional survey. [PDF]
Becker S +5 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Alignment of United States Emergency Medicine Programs' Pregnancy, Parental Leave, and Lactation Policies With Recent Consensus Recommendations. [PDF]
Shepherd LG +16 more
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Survey on the Current Status of COPD Diagnosis and Management Capabilities Among Primary Care Physicians in Pudong New Area, Shanghai. [PDF]
Ling L, Huang Y, Li Y, Huang H, Wang X.
europepmc +1 more source

