Results 41 to 50 of about 358,735 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Apparatus and methods for measuring of the film structures homogeneity degree

Технологія та конструювання в електронній апаратурі, 2009
A design and technological analysis of the scheme for measuring ellipsometric parameters, calculating the refractive index and film thickness has been carried out.
V. A. Makara, V. A. Odarych, T. Yu. Kepich, T. D. Preobragenskaya, O. V. Rudenko   +4 more
doaj  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Organic carbon distribution between structural and process pools in the gray forest soil of different land use

Бюллетень Почвенного института им. В.В. Докучаева
The summarized data on the content of organic carbon (Corg) in the subtypes of gray forest soils occurring on the territory of Russia was presented.
T. N. Lebedeva, D. A. Sokolov, M. V. Semenov, N. B. Zinyakova, S. N. Udal’tsov, V. M. Semenov   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Effects of Early-Stage Treeline Shifts on Soil Microbial Biomass and Catabolic Diversity in Reserved and Grazed Subalpine Meadows

Plants
Treelines are advancing upward on mountain slopes due to climate warming and reduced grazing intensity. However, the effects of initial vegetation changes on soil C, N, and P retention, microbial biomass, and catabolic diversity in the subalpine meadows ...
Kristina Ivashchenko, Anastasiya Romanova, Sofia Sushko, Anna Zhuravleva, Anna Kvitkina, Anna Khodzhaeva, Nadezhda Ananyeva   +6 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Farm-Scale Variability of Soil Organic Carbon Pools in Tilled and No-Tilled Chernozems

Agronomy
Understanding the spatial variability of soil organic carbon (SOC) content and its functional pools under current farming practices is crucial for developing targeted C management.
Sofia Sushko, Kristina Ivashchenko, Yury Dvornikov, Aleksei Dobrokhotov, Alisa Petrosyan, Antonina Grigorova, Gulfina Frolova, Anastasia Romanova, Ekaterina Mukvich, Dmitry Sokolov, Danill Kostetskii, Ivan Alekseev, Vyacheslav Semenov   +12 more
doaj   +1 more source

Effects of Taxon Sampling in Reconstructions of Intron Evolution

International Journal of Genomics, 2013
Introns comprise a considerable portion of eukaryotic genomes; however, their evolution is understudied. Numerous works of the last years largely disagree on many aspects of intron evolution.
Mikhail A. Nikitin, Vladimir V. Aleoshin
doaj   +1 more source