Results 101 to 110 of about 1,586,560 (241)

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

open access: yesFEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya   +3 more
wiley   +1 more source

Topological Aspects of Gauge Theories [PDF]

open access: yesarXiv, 2005
To appear in Encyclopedia of Mathematical Physics, published by Elsevier in early 2006. Comments/corrections welcome. The article surveys topological aspects in gauge theories.
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Francisco Suárez, ¿un científico renacentista? Estado de la cuestión en términos de aproximación bibliográfica

open access: yesFranciscanum, 2020
The document develops a brief introduction to the absence or obscuration of the epistemic doctrine of Francisco Suárez under a triple speculative restriction: 1.
José María Felipe Mendoza
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Mała książka o wielkim wszechświecie

open access: yesZagadnienia Filozoficzne w Nauce, 2021
We live in extraordinary times for cosmologists. A vast amount of new astronomical data is pushing our model of the universe to its limits. An interest in cosmology is growing.
Sebastian Jan Szybka
doaj  

Lessons From Astronomy and Biology for the Mind—Copernican Revolution in Neuroscience

open access: yesFrontiers in Human Neuroscience, 2019
Neuroscience made major progress in unravelling the neural basis of mental features like self, consciousness, affect, etc. However, we nevertheless lack what recently has been described as “missing ingredient” or “common currency” in the relationship ...
Georg Northoff
doaj   +1 more source

Invariances in Physics and Group Theory [PDF]

open access: yesarXiv, 2013
This is a short review of the heritage of Klein's Erlangen program in modern physics.
arxiv  

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

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