Results 81 to 90 of about 1,222,546 (268)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CHIMIA, 1987 The Darwinian concept of evolution through natural selection has been revised and put on a solid physical basis, in a form which applies to self‐replicable macromolecules. Two new concepts are introduced: sequence space and quasi‐species. Evolutionary change in the DNA‐ or RNA‐sequence of a gene can be mapped as a trajectory in a sequence space of ...
openaire +3 more sources
SCIENCE AND RELIGION IN THE UNITED KINGDOM: A PERSONAL VIEW ON THE CONTEMPORARY SCENE
Zygon, 2016 This article considers the current state of the science–religion debate in the United Kingdom. It discusses the societies, groups, and individual scholars that shape that debate, including the dialogue between theology and physics, biology, and ...
doaj +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Retracted: Research on Spectrum Feature Identification of Indoor Multimodal Communication Signal
Advances in Mathematical Physics, 2023 Advances in Mathematical Physics
doaj +1 more source