The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
X-Ray Emission-Line Profile Modeling Of O Stars: Fitting A Spherically Symmetric Analytic Wind-Shock Model To The Chandra Spectrum Of Zeta Puppis [PDF]
X-ray emission-line profiles provide the most direct insight into the dynamics and spatial distribution of the hot, X-ray-emitting plasma above the surfaces of OB stars. The O supergiant zeta Puppis shows broad, blueshifted, and asymmetric line profiles,
Cohen, David H. +2 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Constraints On Porosity And Mass Loss In O-Star Winds From The Modeling Of X-Ray Emission Line Profile Shapes [PDF]
We fit X-ray emission line profiles in high resolution XMM-Newton and Chandra grating spectra of the early O supergiant zeta Pup with models that include the effects of porosity in the stellar wind.
Cohen, David H. +3 more
core +1 more source
A Decade Of Starspot Activity On The Eclipsing Short-Period RS Canum Venaticorum Star WY Cancri: 1988-1997 [PDF]
We present optical photometry of the short-period eclipsing RS CVn system WY Cancri for the years 1988–1997. For each light curve, we model the distortion waves in order to study the behavior of starspots in this system.
Heckert, P. A. +5 more
core +2 more sources
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
DESCARTES AND THE METEOROLOGY OF THE WORLD [PDF]
Descartes claimed that he thought he could deduce the assumptions of his Meteorology by the contents of the Discourse. He actually began the Meteorology with assumptions.
Patrick BRISSEY
doaj
¿Qué tan elementales son los cuatro elementos? Una lectura de Ario Dídimo fr. 21 Diels
[How elemental are the four elements? A reading of Arius Didymus fr. 21 Diels] Arius Didymus fr. 21 Diels is perhaps the single most important source that we have on Stoic elemental theory. The fragment, however, is obscure in many respects and there is
Ricardo Salles
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Looking for Emergence in Physics
Despite its recent popularity, Emergence is still a field where philosophers and physicists often talk past each other. In fact, while philosophical discussions focus mostly on ontological emergence, physical theory is inherently limited to the ...
Joana Rigato
doaj +1 more source

