Results 51 to 60 of about 1,249,497 (268)
How Do Transformers Model Physics? Investigating the Simple Harmonic Oscillator
EntropyHow do transformers model physics? Do transformers model systems with interpretable analytical solutions or do they create an “alien physics” that is difficult for humans to decipher?
Subhash Kantamneni +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Ibn Rushd’s Reception of Aristotle’s Physics
Şarkiyat MecmuasıThe Physics is one of the leading works written by Aristotle on natural philosophy. There are differences in the comments on the Physics because of the way it has been reinterpreted through translations and because of how it relates to certain ...
Cahid Şenel
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DESCARTES ABOUT ANTHROPOLOGICAL GROUNDS OF PHILOSOPHY IN THE "EARLY WRITINGS"
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2018 Purpose of this work is to find the key to understanding the paradox of Descartes’ way of philosophizing during the recourse to the text of "early writings".
А. М. Маlivskyi
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in OncologyPurposeWe present an updated study evaluating the performance of large language models (LLMs) in answering radiation oncology physics questions, focusing on the recently released models.MethodsA set of 100 multiple-choice radiation oncology physics ...
Peilong Wang +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
L’économie de la nature : Fontenelle et le principe de moindre action
Etudes EpistémèIn his Principe de la moindre quantité d’action pour la mécanique (1744), Maupertuis defines the principle of least action as follows: “when some change occurs in Nature, the amount of action used for this change is always the smallest possible”. If this
Christophe Martin
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source