Results 51 to 60 of about 1,659,003 (311)

Methods for Analyzing Pathways through a Physics Major [PDF]

open access: yes, 2016
Physics Education Research frequently investigates what students studying physics do on small time scales (e.g. single courses, observations within single courses), or post-education time scales (e.g., what jobs do physics majors get?) but there is little research into how students get from the beginning to the end of a physics degree.
arxiv   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Mass Extinctions vs. Uniformitarianism in Biological Evolution

open access: yes, 1995
It is usually believed that Darwin's theory leads to a smooth gradual evolution, so that mass extinctions must be caused by external shocks. However, it has recently been argued that mass extinctions arise from the intrinsic dynamics of Darwinian ...
Bak, Per, Paczuski, Maya
core   +3 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Fundamental Dilemmas in Theoretical Physics [PDF]

open access: yesarXiv, 2014
In this paper, we argue that there are foundational dilemmas in theoretical physics related to the concept of reality and the nature of mathematics in physics. Physical theory is treated as a conceptual organism which develops under the weight of its internal contradictions.
arxiv  

The Physics of Flavor is the Flavor of Physics [PDF]

open access: yes, 2001
Summary Talk: International Conference of Flavor Physics (ICFP 2001). Zhang-Jia-Jie. Hunan, China (May / June 2001)
arxiv   +1 more source

Fluctuation Theorem in Rachet System

open access: yes, 2003
Fluctuation Theorem(FT) has been studied as far from equilibrium theorem, which relates the symmetry of entropy production. To investigate the application of this theorem, especially to biological physics, we consider the FT for tilted rachet system ...
Crooks G E   +8 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Physics of Heavy Quarks [PDF]

open access: yesActa Phys.Polon.B27:2667-2676,1996, 1995
Selected problems in heavy quark physics are discussed. The wealth of research problems in this field of physics is stressed.
arxiv  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

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