Results 41 to 50 of about 401,356 (205)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Critical strong Feller regularity for Markov solutions to the Navier-Stokes equations

, 2010
The main purpose of this paper is to show that Markov solutions to the 3D Navier--Stokes equations driven by Gaussian noise have the strong Feller property up to the critical topology given by the domain of the Stokes operator to the power one-fourth ...
Romito, Marco
core   +1 more source

A Survey of Interface Tracking Methods in Multi-phase Fluid Visualization [PDF]

, 2011
A central feature that scientists are interested in is the dynamics of fluid interfaces or the so called material boundaries in multi-fluid simulation .
Chen, Fang, Hagen, Hans
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Lagrangian analysis of alignment dynamics for isentropic compressible magnetohydrodynamics

, 2006
After a review of the isentropic compressible magnetohydrodynamics (ICMHD) equations, a quaternionic framework for studying the alignment dynamics of a general fluid flow is explained and applied to the ICMHD equations.Comment: 12 pages, 2 figures ...
Biskamp D, Braun W, D D Holm, Ertel H, Galanti B, Gibbon J D, Gibbon J D, Gibbon J D Holm D D, Hanson A J, J D Gibbon, Klein F, Kuipers J B, Moffatt H K, Mordant M, O'Connor J J Robertson E F, Priest E, Reynolds A M, Tait P G, Whittaker E T   +18 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Quantification and dosimetric impact of intra‐fractional bladder changes during CBCT‐guided online adaptive radiotherapy for pelvic cancer treatments

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study quantitatively evaluates bladder changes and their dosimetric impact during the on‐couch adaptive process on a commercial CBCT‐based online adaptive radiotherapy (CT‐gART) platform. Methods Data from 183 fractions of ten patients receiving online ART for pelvic cancers were analyzed retrospectively.
Ingrid Valencia Lozano, Elizabeth Buss, Catherine S. Spina, David P. Horowitz, Lisa A. Kachnic, Michael Price, Yi‐Fang Wang, Reshma Munbodh   +7 more
wiley   +1 more source

Improving dose delivery in non‐coplanar cranial SRS: Stereoscopic x‐ray‐guided mitigation of table walkout errors

Journal of Applied Clinical Medical Physics, EarlyView.
Purpose Linear accelerator (LINAC)‐based single‐isocenter multi‐target (SIMT) treatment has streamlined the cranial stereotactic radiosurgery (SRS) workflow. Though efficient, SIMT delivery adds additional challenges that should be considered, including increased sensitivity to rotational errors for off‐isocenter targets.
Yohan A. Walter, Philip F. Durham, Anne N. Hubbard, William E. Burrell, Hsinshun T. Wu   +4 more
wiley   +1 more source