Results 41 to 50 of about 12,257,680 (242)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 morewiley +1 more sourceStructure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.Alex J. Vecchiowiley +1 more sourceSearch for new physics in events with photons, jets, and missing transverse energy in pp collisions at s√ = 7 TeV [PDF]
, 2012 A search for physics beyond the standard model involving events with one or more photons, jets, and missing transverse energy has been performed by the CMS experiment.S. Lynch, Pape, L, M. Maity, V. J. Smith, Berger, J., Kyberd, P., E. Tuovinen, Gilbert, A, Savina, M., Klingebiel, D., Wyslouch, B, Harper, S, Schaefer, C., Mathias, B., Robles, J., Shi, X., Avila, C., El Mamouni, H., Lehti, S., Meyer, AB, Karancsi, J., Benussi, L, G. Steinbr?ck, Petkov, P, Kim, H., Klingebiel, D, Kim, GN, G. N. Kim, Brigljevic, Vuko, D, Koybasi, O., Cossutti, F, Lecomte, P, Kim, JY, E. Laird, Caudron, Julien, Chiochia, V., Kim, JH, Tu, Y., Luckey, PD, Karimäki, Veikko, R. Schmidt, Meyer, A., Svyatkovskiy, A., Rahbaran, B., Wagner-Kuhr, J, Frueboes, T, Eusebi, R, Kukartsev, G., Kinnunen, R, Chakaberia, I., Bortoletto, D, Winstrom, L., Chao, Y., Dasu, S, Toropin, A., Nowak, F., Hohlmann, M., Schlieckau, E, Hadjiiska, R, F. Pandolfi, Kim, DH, Yoo, J, V. Hagopian, S. R. Wagner, Dier-Lamm, A., Autermann, Christian, W. Waltenberger, Khachatryan, V, A. Rosowsky, D'Enterria, D., Romanowska-Rybinska, K., C. Avila, T. J. Kim, Freudenreich, K, Butz, E., D. Polic, Kreis, B., Dalchenko, M, T. Martins, Weng, Y., Pape, L., F. Glege, Eckerlin, Guenter, G. Gomez, Rusack, R, A. Sharma, Glege, F., Bhat, P. C., Z. Antunovic, M. Sharan, Waltenberger, W., Sani, M., Sultanov, G, Olaiya, E, Mercadante, P.G., R. Erbacher, Marrouche, J., Olbrechts, A, D. J. Kong, Harris, P, Goerlach, U., Marcken, G.V, du Pree, T., Zotto, P., Mura, B., Bethani, Agni, Kong, DJ, et al, Guragain, S., F. Micheli, Van Hove, Pierre, J. Damgov, J. Salfeld Nebgen, L. Demortier, Kiesenhofer, W, Florez, C, Whitmore, J, M. H. Ansari, M. Mohammadi Najafabadi, R. Fruehwirth, Yoon, AS, M. Mulders, Ligabue, F, Gouzevitch, M, F.-P. Schilling, Fu, Y., Slaunwhite, J., V. Matveev, Sanchez, A. K., Ford, WT, R. Nandi, Jarry, P., Eckerlin, G, Herve, A, Kellogg, R. G., Sakuma, T., Eads, M., A. Nürnberg, Hadley, NJ, Kyriakis, A, Miceli, T., Klapoetke, K., D. D. Damiao, C. M. Kuo, Heintz, U., Akchurin, N., S. Ragazzi, Luiggi Lopez, E., Paramatti, R., H. A. Salazar Ibarguen, Murzin, V., York, A., M. Serin, W. D. Zeuner, D. Toback, Ostapchuk, Andrey, K. Nawrocki, Peiffer, T, S. Dasu, Andreev, V., Yu, I, Gurpinar, E, Kubik, A., Z. Zhang, Fulcher, J., J.-L. Agram, Guiducci, L., Sogut, K., Kargoll, Bastian, D. Giordano, Janot, P, Iaydjiev, P., Lander, R, Orsini, L., J. Rohlf, Walsh, Roberval, Rikova, MI, Menichelli, M., Tucker, J., Bilki, B, Raidal, Martti, Snook, B, M. Meschini, J. Ellison, Dietz Laursonn, E., Luukka, P, Gouskos, L., Pugliese, G, Topakli, H, Tsirou, A., Mavrommatis, C, Chuang, S. H., Verwilligen, P, G. P. Di Giovanni, L. Millischer, Lellouch, J., Cornelis, Tom, De La Cruz-Burelo, E., Liu, H., Yetkin, T, Gobbo, B, Elvira, V. D., Görner, M., J. Hollar, D. Treille, Smirnov, I., S. Gonzi, Lomtadze, T, Hanson, G., Ford, W. T., S. Linn, Folgueras, S., Maguire, C, Tripathi, M, Segala, M., Millan Mejias, B., Veszpremi, V, Alcaraz Maestre, J., Kotlinski, D, F. Santanastasio, Colaleo, A., Van Remortel, Nick, Kim, MS, M. Choi, A. Savin, M. Simon, Adzic, P., Gouzevitch, Maxime, Cankocak, K, Martschei, D., Uvarov, L, Paramatti, R, Fu, Y, Cankocak, K., Weng, Y, Seidel, M., Avila, C, Korytov, A, M. Felcini, F. Yumiceva, M. Klute, Dominguez, A, P. M. Ribeiro Cipriano, Ellithi Kamel, Ali, D. Leslie, Freeman, J., Galanti, M., Hackstein, Christoph, Kim, Y., R. Gupta, Y. Ban, L. Mundim, Wuerthwein, F, D. Kovalskyi, Ball, G., Lange, W, Y. Bai, M. Khakzad, Akgun, U., Kangal, E. E., M. Dubinin, Davies, G, F. Ratnikov, Tschudi, Y, Röcker, S., Guthoff, M, Kim, ZJ, Puigh, D., Abbiendi, G., Bernardini, J., Golubev, N., Erofeeva, M., I. Glushkov, Koay, SA, S. Kwan, Kaur, M, Lange, J, Lange, D, Kumar, A, Belknap, D., P. Sauerland, I. Bloch, R. Lopez-Fernandez, Kim, V., M. De Palma, Verwilligen, Piet, Kim, TY, Ball, AH, Apresyan, A., Bianchini, L., J. Alimena, Weber, Hendrik, Kim, TJ, Fisher, M, Garcia, J. M. Vizan, Militaru, Otilia, Milosevic, J., B. Pollack, Steinbrück, Georg, Wimpenny, S, Puljak, I, Bellan, R, Rodenburg, M, Azhgirey, I., Blobel, V., A. Popov, Kozhuharov, Venelin, Hooberman, B, Heinrich, M, A. Everett, N. Van Remortel, U. Gebbert, Genchev, Vladimir, Pieri, M., Veeraraghavan, V, Mucibello, L., Gupta, R., S. Frosali, Qazi, S, C. Newman-Holmes, Tytgat, M, S. Sengupta, Kumar, V, N. Demaria, Walsh, R, J. Callner, Walsh, S, Janssen, Xavier, Kreczko, L, Klabbers, P., Lista, L, Leonard, A, M. Abbrescia, Sprenger, D., Teo, W. D., Cali, I. A., Bian, J.G., Garcia-Bellido, A, Sengupta, S, Leonard, J, Gerbaudo, D., Andreev, Yu., C. Veelken, Maravin, Y., Klukas, J., Ribeiro Cipriano, P.M., R. Schofbeck, Y. Maravin, Lopez-Fernandez, R, Gary, J. W., Dasu, S., Hildreth, M, M. Marone, Biasini, M, Ruiz-Jimeno, A, Cuevas, J., R. Covarelli, A. C. Mignerey, Enderle, H, G. Georgiou, Hos, I., Schul, Nicolas, Rossi, AM, Agram, J. -L., M. Gorner, Merz, J, K. M. Chan, Salazar Ibarguen, H. A., Drell, B. R., Montanari, A., K. H. Hoffmann, L. Orsini, Evangelou, I, Hadley, N. J., Malcles, J., Stoykova, Stefka, Vaughan, J, A. Hervé, M. Takahashi, Paoletti, S, Beernaert, K., A. Gilbert, Roh, Y., Thyssen, F, D. Lopes Pegna, Agram, J.-L., Maity, M., Bhattacharya, S., Besancon, M., R. Fr?hwirth, M. Fernandez, Hits, D, Hartmann, F, Eno, SC, Beranek, S, Radburn-Smith, BC, Van Hove, P., Lassila-Perini, Kati, Pellett, D., Calderon, A., Marienfeld, M, Arenton, MW, Zuranski, A., Polic, D, Demina, R, Léonard, A., Jabeen, S., F. Golf, Lemaitre, Vincent, Biino, C, Chatrchyan, S, III, KRP, Uvarov, L., Zucchetta, A, Hou, W-S, Marinho, F, I. Segoni, J. F. de Trocóniz, Bloch, Daniel, Pela, Joao, Beernaert, Kelly, S. H. Chuang, Tadel, M, Betts, R. R., de Fatis, TT, Kuo, CM, Musich, M., Arneodo, M., Giassi, A., Sumorok, K, Milenović, Predrag, Vilar Cortabitarte, R., P. Schleper, Oguri, V., Cali, IA, M. Grothe, Abbrescia, M., Blyweert, S., Behr, Joerg, F. Nowak, M. Diemoz, D. R. Claes, Matchev, K., Meneghelli, M, Farrell, C, Oguri, Vitor, Nogima, H, Spiga, D, Veeraraghavan, V., G. V. Marcken, Y. W. Chang, Tlisov, D, O. Evdokimov, Sguazzoni, G., A. Lopez Virto, R. Demina, Gray, L, N. Varelas, Beni, N., Tully, C, A. Bornheim, Gray, R, E. Di Marco, Cuffiani, M, Leggat, D., Montanari, A, O. Pooth, P. Turner, Kalogeropoulos, A, Iaydjiev, P, Schilling, F. P., Nam, S. K., Beernaert, K, Eerola, P., S. Chauhan, M. Anderson, Naegeli, C, Teodorescu, L., M. H. G., R. D’Alessandro, Yagil, A, Tuovinen, E., G. Tinti, A. Vinogradov, Harris, P., Prado Da Silva, W.L., C. Schäfer, W. Johns, Boos, E., Kesisoglou, S, Torassa, E, Juodagalvis, A, Iaselli, G., Clarida, W, Asawatangtrakuldee, C, Frueboes, T., Drozdetskiy, A., M. U. Mozer, R. Remington, Benvenuti, A. C., St. John, J., Kangal, EE, Lokhtin, I, E. Brownson, Oehler, A., D. Berry, Iiyama, Y., Elmer, P, Ferro, C., A. Pfeiffer, E. Alagoz, Kuessel, Yvonne, N. Mucia, Wagner-Kuhr, J., Incandela, J, Spiezia, A, V. Halyo, M. Johnson, Nirunpong, K, M. Perfilov, Meneghelli, M., M. Verzetti, Yun, JC, J. Dolen, S. Mueller, Sabes, D, Rander, J., N. Heracleous, G. Majumder, D\u27hondt, J., Castello, Roberto, Verdier, P., J.-P. Merlo, J. Strauss, Kim, T. Y., F. Romeo, D. M. Figueiredo, Flucke, G., Marangelli, B, Ro, SR, M. Besancon, Chuang, SH, J. Krolikowski, R. A. Ofierzynski, Akgun, B., Brownson, E., Santaolalla, J, Schroder, M, Zakaria, M., J. Molnar, Dias, F.A., S. Chang, Hreus, T., Martin, MA, Baumgartel, D., Ganguly, S, Green, D., Kousouris, K., F. J. Ronga, Jeng, GY, J. Olsen, Hartl, C., L. Ceard, L. Fanò, Ero, J, Ghete, V.M., Apyan, A., Puigh, D, BELFORTE S., Grunewald, M., Alcaraz Maestre, J, Akchurin, N, Harper, S., Ryan, M. J., Rodrigues Antunes, Joao, Sphicas, P, M. M. Obertino, Olaiya, E., D. Dobur, Richman, J, A. Karjalainen, S. C. Tonwar, Garcia-Abia, P., M. Naimuddin, Ko, W, Romeo, F, Breuker, H., B. Gobbo, Rosin, Michele, Creanza, D, Sigamani, M., Goldstein, J, Broutin, C., S. Meola, Makouski, M, Chwalek, T, Bertl, W., CMS, Maselli, S., S. Ganguly, Marone, M., S. Won, Gozzelino, A., Adair, A., Bostock, F., Torre, P., N. Mccoll, Kubota, Y., Gennai, S, Maksimovic, P., Hoeing, R. S., A. T. Meneguzzo, E. Clement, Sinthuprasith, T., Durkin, LS, Miller, D. H., Duchardt, Deborah, S. Wayand, Son, T, Van Mechelen, Pierre, S. Duric, D'agnolo, R. T., Ryu, G, Fabbro, B., Dimitrov, Anton, Hauk, J, R. K. Choudhury, Kravchenko, I, Travaglini, R., Zang, Jingjing, Valls, N., G. Y. Jeng, Alda Junior, WL, Tschudi, Yohann, Van Doninck, Walter, V. Rekovic, Kim, T. J., Eno, S. C., Gollapinni, S, Moon, DH, Meng, X, Castro, Elena, Dorigo, T., Gigi, D, Magnan, A-M, C. Hackstein, Berry, D., Velasco, M, Beaudette, F, C. Sander, W. D. Boer, Troendle, D., G. Flugge, B. Hegner, Sandra S. Padula, Flix, J, A. Van Spilbeeck, E. Yazgan, Hegeman, J, M. , Finger J.r., Wakefield, S, Lazo-Flores, J, T. Hebbeker, Mott, A., Berry, E., Goerlach, Ulrich, Harvey, J., Brinkerhoff, A, Haj Ahmad, Wael, Charlot, Claude, Perrotta, A, Dominguez Vazquez, D., Santaolalla, J., Erfle, J, B. Safarzadeh, Harris, RM, Wu, W., L. Tauscher, Tomalin, I. R., M. Donegà, Luukka, Panja-Riina, Eusebi, R., Pitzl, D, A. Bhatti, W. Adam, Marrouche, J, Tiras, E, Tschudi, Y., L. Barbone, A. Toropin, Kilminster, B., Silvestris, L, Ekmedzic, M, De Benedetti, A, Evstyukhin, S., Campagnari, C, Ronchese, P., S. Chatrchyan, Steinbrück, G., T. R. Fernandez Perez Tomei, Paus, C., Benedetti, D, Venditti, R, Kraan, A, Klukas, J, Gurrola, A, Vanelderen, L, Hunt, A, Perries, Stephane, D. Cussans, Innocente, V, Meschi, E., Boudoul, Gaelle, V. Innocente, Pandolfi, F, P. Raics, Juillot, P, Perrey, H, Held, H., Jabeen, S, M. Zeise, M. B. Tonjes, Majumder, D., R. Klanner, De Benedetti, A., Chang, YH, M. , Correa Martins J.r., Karchin, P. E., Wissing, C., A. O. M. Iorio, P. Bargassa, Palinkas, J., Seo, H., Konoplyanikov, V, Barbagli, G, J. Caudron, Horisberger, R., K. Doroba, Wulz, C. -E., K. Kaadze, B. Casal, Konecki, M., Beliy, N, Gomez, JA, Mall, O, Naumann-Emme, S, Agram, J-L, Chao, Y, Ott, J., Chang, YW, Bodin, D, Spalding, W. J., R. Travaglini, J. Lingemann, Dominguez, A., Gomez, JP, C. Kottachchi Kankanamge Don, Eads, M, Balazs, M, El Mamouni, Houmani, Avdeeva, E., Fay, Jean, Loveless, R, Takahashi, M, Ratti, S. P., T. d. Pree, Smirnov, V., Fassi, Farida, B. C. RadburnSmith, Raidal, M., Martinez Rivero, C, G. I. Veres, J. H. Kim, Davies, G., A. Lanev, G. Petrucciani, Gallinaro, M, Grigelionis, I., M. Selvaggi, Fabbri, F, Musella, P., Wittich, P., Fay, J., Saka, H., B. Lutz, D. Krucker, Stoye, M., Azzurri, P., Malvezzi, S., Choudhary, BC, Y. Cho, Elmer, P., Ptochos, F., Fiori, F, Nessi-Tedaldi, F., Sturdy, J., C. Grandi, Govoni, P., Eggert, N., Gronberg, J, T. Kamon, L. Rebane, V. Oguri, Le Bihan, AC, Zhu, RY, Kaufman, GN, D. Ryckbosch, B. Ille, Long, OR, Fassi, F, Civinini, C., Barth, C., Gomez, G., O. Dogangun, Krücker, D., Shah, M. A., Vanelderen, L., Nash, J., Castilla-Valdez, H., E. E. Kangal, Goh, J., de Barbaro, P, Maes, M., Chadwick, M., M. Vergili, Majumder, G., Leonardo, Nuno, H. Pieta, Padula, Sandra S., Wardle, N, Ceard, L., Schmidt, A, V. Epshteyn, S. V. Gleyzer, Osorio Oliveros, A. F., Ranjan, K, Muniz, L, P. Van Mechelen, N. De Filippis, O. Charaf, N. Odell, Schmidt, R, Amsler, C., Jussen, R., A. Chatterjee, J. Draeger, Vinogradov, A, Mäenpää, Teppo, Duris, J, P. Gras, Eckstein, D., Snowball, M, A. Potenza, S. Di Guida, Kaadze, K., L. Di Matteo, Antunovic, Z., I. Azhgirey, P. Geffert, Krammer, Manfred, J. Tucker, Soares, M. S., Petridis, K., Nef, P, Dabrowski, A, H. Rohringer, S. W. Li, Soares Jorge, Luana, Hughes, R., Ecklund, K. M., E. Tiras, Apanasevich, L, D. Renker, A. Snigirev, Gülmez, E., Zeise, M., Gavrilenko, M., L. Thomas, Rios, AAO, Barth, Christian, Korpela, A., Hebbeker, T., IORIO, ALBERTO ORSO MARIA, Cole, JE, C. Battilana, P. Siegrist, Mccartin, J, K. W. Bell, Duarte, J., Tiko, A., H. K. Wöhri, Venturi, A., M. Sharma, Nash, D., Hays, J, Pol, Maria Elena, Mankel, R, Bergauer, T, Dominik, W, H. C. Kaestli, Lannon, K, Khalatyan, S., A. Gueth, Quintario Olmeda, A., Liao, Junhui, Organtini, G., D. Liang, T. S. Anjos, Arcidiacono, R., Choi, M, Choi, Y, Leonardo, N, D. Dutta, Gude, A., Choi, S, A. Rinkevicius, Veszpremi, V., D. Ungaro, J. A. Coughlan, S. Tosi, Lustermann, W., Cerci, S, Heo, SC, O'Brien, C, Lincoln, D., Flanagan, W, Elgamma, S., Arce, P., Dinardo, ME, M. Ivova Rikova, Reyes-Santos, M. A., Paulini, M, Jeitler, M., Basegmez, S., Hunt, A., Steggemann, J., Aguilar-Benitez, M, Schum, Torben, Vanini, S, Blumenfeld, B, N. Shumeiko, V. Gavrilov, Harvey, J, Chetluru, V, Evans, D, Meneguzzo, A. T., Meridiani, P, David, A, Strauss, J., Palla, F, Wolf, M., Kao, KY, Busson, Philippe, Cossutti, F., Z. Szillasi, Schäfer, C., S. Xie, G. R. Snow, Erbacher, R., Ignatenko, M, Maes, M, Tuovinen, Esa, Chabert, E.C., P. G. Verdini, Hong, B, Zaganidis, Nicolas, C. Henderson, Ochesanu, S, G. M. Dallavalle, Ricci-Tam, F., Abbrescia, M, Gataullin, M., Adair, A, Gallo, E, D. D. Jesus, Harr, R., De Cosa, A, Mirabito, L., Maruyama, S., E. A. De, Beliy, N., Velkovska, J, Williams, T., Ille, Bernard, Panagiotou, A., V. Veszpremi, Landsberg, G., Savrin, V., Onel, Y., Pesaresi, M, Sarycheva, L, Garcia, G., Cumalat, J. P., Erhan, S, G. B. Mohanty, Riedl, Caroline, Dünser, M., Shrestha, S., Van Mechelen, P +999 morecore +1 more sourceEpigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan +4 morewiley +1 more source‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...Jack P. K. Bravowiley +1 more sourceArtificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...Leonardo Andreoni, Alberto Crediwiley +1 more sourceReport and recommendations on multimedia materials for teaching and learning quantum physics [PDF]
, 2015 An international collaboration of physicists, affiliated with Multimedia Physics for Teaching and Learning (MPTL) and MERLOT, performed a survey and review of multimedia-based learning materials for quantum physics and quantum mechanics.Mason, B, Silva, J, Santi, L, Kohnle, A, Melder, T, Girwidz, R, Dębowska, E, Arpornthip, T, Greczyło, T, Michelini, M +9 morecore +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more source
