Results 21 to 30 of about 72,971 (215)

Diamond Prototypes for the ATLAS SLHC Pixel Detector

, 2009
Vertex detectors at future hadron colliders will need to cope with large particle fluences. Diamond is a particularly radiation hard material and exhibits further properties that makes it an attractive material for such detectors.
Belau, Lari, Markus Cristinziani, Mathes, Treis   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Measurement of the effect of Non Ionising Energy Losses on the leakage current of Silicon Drift Detector prototypes for the LOFT satellite

, 2014
The silicon drift detectors are at the basis of the instrumentation aboard the Large Observatory For x-ray Timing (LOFT) satellite mission, which underwent a three year assessment phase within the "Cosmic Vision 2015 - 2025" long-term science plan of the
Azzarello, P., Bozzo, E., Campana, R., Del Monte, E., Diebold, S., Evangelista, Y., Feroci, M., Perinati, E., Pohl, M., Rachevski, A., Vacchi, A., Zampa, G., Zampa, N.   +12 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Simulation of gain stability of THGEM gas-avalanche particle detectors

, 2017
Charging-up processes affecting gain stability in Thick Gas Electron Multipliers (THGEM) were studied with a dedicated simulation toolkit. Integrated with Garfield++, it provides an effective platform for systematic phenomenological studies of charging ...
Azevedo, C. D. R., Breskin, A., Bressler, S., Correia, P. M. M., Oliveira, C. A. B., Pitt, M., Silva, A. L. M., Veenhof, R., Veloso, J. F. C. A.   +8 more
core   +1 more source

Measurements of Sub-degree B-mode Polarization in the Cosmic Microwave Background from 100 Square Degrees of SPTpol Data [PDF]

, 2015
We present a measurement of the $B$-mode polarization power spectrum (the $BB$ spectrum) from 100 $\mathrm{deg}^2$ of sky observed with SPTpol, a polarization-sensitive receiver currently installed on the South Pole Telescope.
Ade, P. A. R., Aird, K. A., Austermann, J. E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Cho, H-M., Citron, R., Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., Gao, J., George, E. M., Gilbert, A., Halverson, N. W., Hanson, D., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hoover, S., Hou, Z., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Keisler, R., Knox, L., Lee, A. T., Leitch, E. M., Li, D., Luong-Van, D., Marrone, D. P., McMahon, J. J., Mehl, J., Meyer, S. S., Mocanu, L., Natoli, T., Nibarger, J. P., Novosad, V., Padin, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Zahn, O.   +65 more
core   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Transmissive X-ray Polarimeter Design For Hard X-ray Focusing Telescopes

, 2015
The X-ray Timing and Polarization (XTP) is a mission concept for a future space borne X-ray observatory and is currently selected for early phase study. We present a new design of X-ray polarimeter based on the time projection gas chamber.
Deng, Zhi, Dong, Yongwei, Feng, Hua, Han, Dong, He, Li, Heng, Peiyin, Ji, Jianfeng, Li, Hong, Li, Tenglin, Liu, Yinong, Lu, Fangjun, Wu, Qiong, Zeng, Ming, Zhang, Shuangnan   +13 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Feedhorn-coupled TES polarimeter camera modules at 150 GHz for CMB polarization measurements with SPTpol

, 2012
The SPTpol camera is a dichroic polarimetric receiver at 90 and 150 GHz. Deployed in January 2012 on the South Pole Telescope (SPT), SPTpol is looking for faint polarization signals in the Cosmic Microwave Background (CMB).
Ade, Peter A. R., Aird, K. A., Austermann, J. E., Beall, J. A., Becker, D., Benson, B. A., Bleem, L. E., Britton, J., Carlstrom, J. E., Chang, C. L., Cho, H.-M., Crawford, T. M., Crites, A. T., Datesman, A., de Haan, T., Dobbs, M A., Everett, W., Ewall-Wice, A., George, E. M., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holland, Wayne S., Holzapfel, W. L., Hubmayr, J., Irwin, K. D., Karfunkle, M., Keisler, R., Kennedy, J., Lee, A. T., Leitch, E., Li, D., Lueker, M., Marrone, D. P., McMahon, J. J., Mehl, J., Meyer, S. S., Montgomery, J., Montroy, T. E., Nagy, J., Natoli, T., Nibarger, J. P., Niemack, M. D., Novosad, V., Padin, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Story, K., Tucker, Carole, Vanderlinde, K., Vieira, J. D., Wang, G., Williamson, R., Yefremenko, V., Yoon, K. W., Young, E.   +61 more
core   +1 more source