Results 31 to 40 of about 6,267 (243)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan +4 morewiley +1 more sourceThe pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich +7 morewiley +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more sourcePerformance studies of the CMS strip tracker before installation [PDF]
, 2008 This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2009 IOPIn March 2007 the assembly of the Silicon Strip Tracker was completed at the Tracker Integration Facility at CERN ...Brom J-, Broccolo, B., J. D'HONDT, Wickens J, Drouhin F, Luzhetskiy N., Mattiazzo S., C. CAMPAGNARI, D. MASON, P. BARINGER, Sarkar S, Yang, Z., Petagna P., Jeng G. Y., Serban, AT, Bainbridge R., De Weirdt, S., Pooth, O, Kalavase, P, Mammini, P, Abbaneo, D., Delattre, M., E. DE LANGHE, Borrello L, Bernardini J., Covarelli, R., Adler V., Steininger H, Maes J., T. LOMTADZE, Paccagnella, A, Miner, D, Pozzobon, N, Profeti A, Lowette, S, Petragnani G., Zoeller MH, Ligabue, F., Rubinstein, N, Wilke L., A. MOGGI, M. COSTA, Haroutunian, R, Steinbrueck G, Hashemi, M., Gerber, CE, Contardo, D., Trocme, B., J. MAES, Kloukinas, K, R. ROSSIN, Chierici R., Paoletti S, Huhtinen M, Servoli, L., Chiochia, V., Romero A., Pesaresi M., Raupach F, White D, Macchiolo, A, Zerev E, H. J. SIMONIS, Checcucci B, de Wolf E. A., Ernenwein J-, V. POSTOLACHE, Rouby, X., S. HEIER, Tosi, M., Mariani F., A. BASTI, P. R. HOBSON, Widl E., Ciulli V., Moulik T, De Boer, W., Coughlan J., Foa, L, LAE CK, Albergo S., de Wolf, E. A., Bianucci S., Slav A., Fahrer M, Wickens J., Gillissen C., Mills C, Kreyer, S, T. MENP, Bhat, PC, Schirra F., L. FOA, Gateau M, O. ZORBA, Siegrist P., Villella, I, Dell'Orso, R, Burke S, Raffaelli, F, Heyninck, J, DEWULF JP, Pernicka M., Scarlini E, Gregoire G., Nigro M., ERNENWEIN JP, Donckt, MV, G. MARTINELLI, D'Alessandro R., E. CHABERT, Chen J, C. KUKULIES, Johnson, M, Dragicevic, M, Lamb J, Luukka, PR, Zhukov V, Butz, E., Ernenwein, JP, Noeding C., Anagnostou, Georgios, J. RIBNIK, T. LIAMSUWAN, Karpinski, W, Tonelli G., Adam W, Schleper, P, Mäenpää, T., Simonis H-, Pierschel, G., Johnson M, Onnela, A, Rizzi D, Noy, M, Delmeire, E., Tuve C, Hobson, P.R., Kalavase P, Rizzi A, Waltenberger, W., Wlochal, M., Regenfus C, Bonnevaux, A., Giraud N, Bacchetta N, Bruno G., R. BRAUER, Taghavi, S, Harris, P, Balestri, G., M. MESCHINI, Goerlach, U., K. H. HOFFMANN, Roberfroid V, Krammer, M, JENG GY, Bracci F., Beaumont, W., G. ANAGNOSTOU, Mason D., M. GALANTI, Zatserklyaniy, A, Bonnevaux A, Vander Velde, C., Fiori, F., Migliore, E., Marage P, et al, Liamsuwan T., Tonelli G, Schmidt, Alexander, Hoffmann, K.-H., M. BIASINI, R. BLAES, Mozer M, Cariola P, Sigaud C, Van Lancker L., Tomalin I., Luukka, P.R., Hansel, S, Jensen, H., Galanti, M, Delaere C, Vanlaer, P, Fahrer M., Spiga, D., Lenzi, P., Sanguinetti, G, Ledermann, B, Ligabue, F, G. Y. JENG, Karpinski, Waclaw, Lounis A., HOFFMANN KH, Tropea, P., Tolaini, S, Sguazzoni, G, Saizu M. A., M. DE PALMA, Michal, S, Chabanat E., Goorens R, Burkett K., Guardone, N, Zorba, O., F. YUMICEVA, C. K. LAE, D. BISELLO, Bacchetta, N, O. VAN DER AA, Raffaelli F, Anghel I, K. KLEIN, R. GOORENS, Hammad G, Pesaresi M, Crook A., Gill, K, Affolder, K, Delmeire E, Steck P., N. BACCHETTA, A. BOCCI, Affolder, T, S. FROSALI, Cole J, Ronga, F., Thomas M, Giammanco A., M. STOYE, Parrini, G, Gross, L, Allen A., Wingham, M, Giraud, N, Vanlaer P, Mozer M., D'Alfonso M., Basti, A, Keutgen T, Schmidt, A., Berretta L., D. NGUYEN, Cattai A, Hamdorf R, D. ABBANEO, Chiorboli, M, Kortesmaa, J, Dumitrache, F, Anttila, E, Barge D., De Palma M, Burke, Samuel P., My S., Simonis, H.-J., Berretta L, Kyre, S., Preda M., Simms L, Abbaneo D., A. U, SCHEURER, Fulcher, J., Pantano, D., Pernicka M, Swain, S., De Filippis, N., Silvestris L, D'Alfonso M, Edera, L.M., Lariccia, P, E. CHABANAT, Bosi, F, J. HOSSELET, Garberson, J., Dewulf, J.-P., Venturi, A, Biasini M, Cariola P., Jaditz, S, Bean A, De Mattia M., de Lentdecker G., O. BUCHMULLER, Zaccarelli, L, Flucke, G, Giorgi M, Rebassoo, F, Chabert E, Eppard, M., O. CHARAF, Zito, G, Karimaki V, Raupach, Frank Arthur, Baulieu, G., A. GIAMMANCO, Schwering G, Miao T, Heyninck J, Alagoz, E, Tsirou, A., I. PAL, Boudoul, G., Buchmuller O, Selvaggi, G., Cerati G, A. CATTAI, Manna N., N. LUMB, Liu, H., A. FURGERI, Meschini, M, Piccut C, Mannelli, M., U. GOERLACH, Lomtadze, T, Tuominen, E, Landi, G., Hanson, G., Hrubec J, Demaria N, Schwering, G, C. CERRI, Buhmann, P, D'Hondt, J., G. PETRUCCIANI, Sanhueza, S, Giordano D., Bianucci S, Bock, E, Hall, G., Saizu, M.A., Sigaud C., Devroede, O, Kostesmaa, J, Radicci, V., Abbaneo D, Clerbaux B, Zorba, O, Berst, JD, J. C. FONTAINE, Focardi, E, Magini N, Ambroglini F, Olzem J., Delmeire, E, Frosali S, Spiegel L, Vander Donckt, M., Eppard M., Breuker H., T. LAMPEN, P. EVERAERTS, Grabit R, Oberegger M., Ronzhin, A., G, PASZTOR, Ribnik J, Dobur, D., G. BAGLIESI, Amsler C, Galanti, M., Hinchey C., Goitom, I, Bhat, P.C., G. TONELLI, Mc Guinness, C, Dell'Orso, R., Leonardo, N., De Filippis N., G. PIERSCHEL, V. KHOMENKOV, Karpinski W, P. VANLAER, Cazzola, U., Lariccia P, Petrucciani G., Broccolo B., Azzi P., Kostesmaa, J., Pozzobon, N., Sprenger D., Beaumont W., T. BERGAUER, Sutera, C., Vanzetto S., C. NOEDING, Butz E., Kaminski, J, Mirabito, L, Jeng, G.Y., Poettgens M., Clerbaux B., Swain S., Maletta, F, Kottelat L. J., Bernardini, J., Delaere, C., Villella, I., Benotto, F, Gelin G, Sigaud, C., Robmann, P, R. D'ALESSANDRO, Martinelli G, Khomenkov V., CALZOLARI, FEDERICO, Hashemi M, Berst, J.-D., C. GENTA, P. AZZI, Sharp P., R. COVARELLI, Steininger, H, Anagnostou G, Pooth, Oliver, Elgammal, S., Moccia, S., Siegrist, P., G. SANGUINETTI, Adler V, Blaes, R., Edera, LM, Tsirou A., Schael, S, F. DROUHIN, P. TROPEA, Azzi P, Brianzi M, Mueller T.h., Radicci, V, Kukulies C, Roberfroid, V, Fulcher J., K. PIOTRZKOWSKI, Steinbruck, G., Militaru, Otilia, MUFFAT JOLY J, Skup, E., K. V. TSANG, Segneri, G, T. MOULIK, Hrubec J., Manolescu F., Preda, M., Scarlini E., Skup, E, Benucci L., Genta, C., Creanza, D., R. HAROUTUNIAN, E. FORTON, Moccia S., I. REID, Postema H, Simonis, H.J., De Palma M., Mc Guinness C, Ledermann B, Berst, J.D., Tessaro M., G. BRUNO, Devroede, O., Bean, A., K. A. HAHN, Mason, D., Guardone N, Raupach, F., Ulmer, K.A., Delaere C., Covarelli R, Agram J. L., Ribnik, J, Feld L., Dietch, J., Kyre S, P. SPAGNOLO, Friedl, M., Santocchia A, Baringer, P, Karimaki V., D. CONTARDO, Brauer R, Bazterra VE, Thomas, M, Bagliesi, G, M. FRIEDL, Covarelli, R, Ostapchuk, A., Sprenger, D., Hinchey C, Tenchini R., Lamb, J., Nigro, M., O. DEVROEDE, Avanzini C, Chabanat E, Bagliesi, G., Van Mechelen P, P. BLM, N. MANNA, Didierjean F, Jensen, H, Lamb, J, Hashemi M., T. MIAO, Biasini, M, Postema, H, Giudice, N., Stuart D., W. SPALDING, Tropea P., Lowette S, Shah, Y, Harkonen J., Steiner S, J. TROSKA, Della Negra, R., Mannelli M, Gay A, Mueller S, Vanzetto, S., Blum, P., Mueller T, Maletta F, Cattai, A., Korjenevski, S, Giorgi, M., Anagnostou G., Tuominen E, Bergauer T, Klein, K., Campagnari, C., De Mattia, M., Stoye M., Linn A, Magazzu G., Olivetto, C., Grabit, R., D. KOVALSKYI, Paoletti, S, Demaria, N, Olivetto C., Pein, U, Civinini C, Bean A., Selvaggi G, Syed, A., L. BORRELLO, Drouhin F., Sparti V, Tropea P, Friedl M., Calzolari F., Agram, J.-L., Albergo, S., Hoffmann, K.H., Beissel, F, Serban AT, Hartmann, F, SCHILLING FP, Benucci L, Tessaro M, Ricci D, Van Hove, P., Goitom, I., Piotrzkowski K., Bluem P., Yang Z., M. MASSA, Giordano D, Fulcher J, Ribnik, J., Farano R., K. SUNG, Tuominiemi J, Steiner, S, Mannelli, M, Boudoul, G, S. MLLER, G. MAGAZZU, Martin, C, Gerber CE, Ahmed I., Teodorescu, L, Staszak, D., Kaminsky A, Zhukov, V, Demina, R, Giolo-Nicollerat, A.S., Spalding, WJ, Akhtar I, Lemaitre, Vincent, J. CHEN, Elgammal S., W. KARPINSKI, Foa, L., Della Negra R., Boccali, T, T. BOCCALI, Profeti, A., Yang Z, Buhmann, P., Hosselet J., S. NAHN, Giorgi, MA, Rommerskirchen T, Rommerskirchen T., Gay A., Velde, C.V., Ernenwein, J.-P., Zaccarelli, L., Regenfus, C., B. DE CALLATAY, Miao, T, Hermanns T, Hartmann, F., Furgeri, A, T. HERMANNS, Selvaggi G., Messineo, A, Heydhausen D, S. DE WEIRDT, N. CRIPPS, Masetti L, Brauer, R., Klanner, R, Tricomi, A, Giassi, A., Schmid, S, Fontaine, J.C., Esser, Hans, Butt, S, Pasztor, G, Heyninck, J., Ricci D., Wastiels C, Tuve, C, S. PAOLETTI, Gateau, M., Spiga, D, Esser H., Marchioro A., Robinson R, Brom, J.M., Schilling F-, D. STUART, Macchiolo A, Raupach, F, Klein K., Beissel F, U. PEIN, Sguazzoni, G., Borgia MA, Hermanns, T., Linden T., Hahn, KA, P. SHARP, Reznikov S, Fiore, L, A. ROMERO, Bagliesi G, Muller, S., S. KHALATIAN, Shah, Y., Borrello L., M. FREY, R. FRHWIRTH, Teodorescu, L., Dewulf J. P., F. VASEY, Zito G, Liu H., Nigro M, Caponeri, B., Kaminski, J., F. PALMONARI, Kreyer S, J. RICHMAN, Lemaitre V, Delattre M, Kartashov D., Teyssier D, Harkonen J, Stahl A, Marcantonini, M, Caponeri B., J. D. BERST, M. GIORGI, Kraan A, Perchalla L., Olzem J, Pantano D, Hosselet, J., Mersi S., Bisello, D, J. TUOMINIEMI, Sala, G, Kortesmaa J, Frühwirth, R., Troska J, Manna N, Giubilato, P, Anagnostou, G., P. TEMPESTA, Contardo D., I. ANGHEL, Muller, T., Schilling F. P., Goorens R., Incandela, H, Giammanco, A., Ulmer KA, Zerev E., Sparti V., Bhat P. C., Incandela, J, Van Mulders, P, Wittmer B., Mantovani G., S. ASSOUAK, Ostapchuk A, Reid, ID, T. MLLER, Daubie E., S. DUTTA, Dierlamm A, F. BOSI, Sentenac, D., P. AZZURRI, Profeti, A, Reid, I., G. LANDI, Dutta S, Spiga D., Hosselet J, Garberson, J, White, D., Trocme, B, S. SWAIN, Flucke, G., Hermanns T., Tomalin I, Maazouzi, C., Ronzhin A, Giudice N., Sharp, P., Luzhetskiy, N., Raymond, DM, A. TRICOMI, A. GIASSI, Robinson, R, Palmonari F., Bilei, G.M., Ceccanti M., Cripps N., B. TROCME, P. GRAEHLING, Liu H, E. BOCK, Demaria, N., Santocchia A., Babucci, E, Vanlaer, P., I. GOITOM, Perries S., Dietch, J, Checcucci B., Grabit, R, Sharp P, Stoner J., Flugge G., Jeng, GY, Marcantonini M, Keutgen, Thomas, Edera L. M., Linden, T, Maggi G., Militaru, O, Michal, S., S. LINARI, Maenpaa T., L. MIRABITO, Guillot, G, Mariani, F., BONNET JL, Pal, I, Pandoulas D, Dorigo, T, Bonnet, Jean-Luc, Genta C, Gutsche, O, Masetti L., Petragnani G, Nikolic, M., J. HRUBEC, Beissel, F., Tuominiemi J., Linn, A., W. WALTENBERGER, Richman, J, Castaldi R, Michotte, D, Bouhali, O, Noto F., Marchioro, A, Kcira D., Abbas, M., Breuker, H., Garberson J, Ahmed I, Dupasquier, T, Maazouzi C., Gregoire G, Keutgen, Th., Creanza, D, Dierlamm A., Ronga F., Tkaczyk S., Nguyen, H., Genta C., Parrini G, Bocci, A, Civinini C., Cerati, G., Karimaki, V, Lungu GA, Schmid S, Stark R., Khalatian, S., Furgeri A, Dutta, S ., Brianzi, M, Heier, S, Cerati, GB, Focardi, E., Fahrer, M., G. GREGOIRE, Gennai, S, Maes, J., Costa S., Raymond D. M., K. GILL, H. LIU, Moggi, A, Steininger H., D. ORBAKER, Tolaini, S., Abbas, M, Paccagnella, A., Devroede O, J. HRKNEN, Costa, M., Cattai, A, J. P. DEWULF, Engstrom P, Giolo-Nicollerat, A.-S., Pein, U., S. KORJENEVSKI, Guardone, N., Hauk, J, Costa S, Rolandi G., Schmid, S., Costa M, Karaevski S, Kottelat, L.J., Tricomi, A., Costa M., Martinelli, G., Pioppi M., P. LENZI, Johnson, M., Dorigo, T., A. PACCAGNELLA, Piccut C., Marage P., Baringer P., L. M. EDERA, Spiegel, L, Albert, E, Costa, S., M. CHIORBOLI, Ciulli, V., Shah Y., Servoli, L, Amsler C., Mills, C, Jaditz S, Fruehwirth R., Wagner S. R., Crook A, Noto, F., Everaerts, P, Lampen T., Hoffmann K. H., Stringer, R, Manolescu F, Frey, M., Stark, R., Hanson G., Skup E, A. VENTURI, Raffaelli, F., Postolache V., Kaussen, G, Cazzola, U, Charaf, O, Castello, R, Gelin, G., Loreti M., Speer, T, S. SCHAEL, Wittmer, B., A. S. GIOLO NICOLLERAT, H. JENSEN, Schilling, F.-P., De Mattia M, D. MICHOTTE, Avanzini, C, Chiochia, V, M. CARDACI, Gross L, Martinelli G., Goerlach, U, Maes J, Giolo-Nicollerat, AS, Cardaci, M., S. KYRE, Chen J., Tavernier, S, Silvestris, L, Babucci, E., A. STAHL, Tomalin, I., L. VAN LANCKER, de Wolf EA, Fano L, Nikolic, M, Lumb N, Dutta, S., Ostapchuk A., Sentenac D., Frey, M, Albert, E., Pantano D., Bhat PC, Benedetti, D, Kraan, A, Giolo-Nicollerat A-, Stahl, A, Ferorelli R, Teyssier, D., J. HEYNINCK, C. E. GERBER, Kyre S., L. SPIEGEL, P. KALAVASE, Farano R, Wagner, S.R., Juillot, P, Van Lancker, L., Burke S., Hall G, Flucke G., Chabanat, E., Ligabue F, Wlochal, M, Hall, G, Linari S, Martin, C., Ranieri, R, J. BERNARDINI, De Weirdt S, C. VANDER VELDE, Pandoulas D., Czellar S., Spalding WJ, A. T. SERBAN, J. GARBERSON, Nguyen H., Ljuslin C., G. DIRKES, Bagby L., Cerri, C, S. R. WAGNER, Piotrzkowski, Krzysztof, Roberfroid, V., Preda M, Pozzobon N, de Langhe E., Cihangir, S, Sarkar, S., Incandela, J., Rizzi, D., E. SKUP, N. DEMARIA, Kcira D, Strub R. +999 morecore +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceAutomated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller +6 morewiley +1 more sourceThe attenuation of atmospheric Cerenkov photons [PDF]
, 2002 Whilst the atmosphere places a limit on the successful applications of many branches of astronomy, it becomes an invaluable tool for the detection of very high energy γ-rays. This thesis is concerned with reducing the systematic uncertainties inherent to Daniel, Michael Kevin, Daniel, Michaelcore +1 more source14th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications
, 2014 The exploration of the subnuclear world is done through increasingly complex experiments covering a wide range of energy and performed in a large variety of environments ranging from particle accelerators, underground detectors to satellites and the ...Price, Lawrence, Rancoita, Pier-Giorgio, Leroy, Claude, Ruchti, Randy, Giani, Simone +4 morecore +1 more source
