Results 51 to 60 of about 2,706,964 (293)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Suppression of Zeno effect for distant detectors [PDF]

, 2006
We describe the influence of continuous measurement in a decaying system and the role of the distance from the detector to the initial location of the system. The detector is modeled first by a step absorbing potential. For a close and strong detector, the decay rate of the system is reduced; weaker detectors do not modify the exponential decay rate ...
arxiv   +1 more source

Evolution of Complexity in Out-of-Equilibrium Systems by Time-Resolved or Space-Resolved Synchrotron Radiation Techniques

, 2019
Out-of-equilibrium phenomena are attracting high interest in physics, materials science, chemistry and life sciences. In this state, the study of structural fluctuations at different length scales in time and space are necessary to achieve significant ...
Bianconi, Antonio, Campi, Gaetano
core   +1 more source

Space Detectors for Gamma Rays (100 MeV - 100 GeV): from EGRET to Fermi LAT [PDF]

, 2015
The design of spaceborne high-energy (E>100 MeV) gamma-ray detectors depends on two principal factors: (1) the basic physics of detecting and measuring the properties of the gamma rays; and (2) the constraints of operating such a detector in space for an
Thompson, David J.
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Simulation of gain stability of THGEM gas-avalanche particle detectors

, 2017
Charging-up processes affecting gain stability in Thick Gas Electron Multipliers (THGEM) were studied with a dedicated simulation toolkit. Integrated with Garfield++, it provides an effective platform for systematic phenomenological studies of charging ...
Azevedo, C. D. R., Breskin, A., Bressler, S., Correia, P. M. M., Oliveira, C. A. B., Pitt, M., Silva, A. L. M., Veenhof, R., Veloso, J. F. C. A.   +8 more
core   +1 more source

SPT-3G: A Next-Generation Cosmic Microwave Background Polarization Experiment on the South Pole Telescope [PDF]

, 2014
We describe the design of a new polarization sensitive receiver, SPT-3G, for the 10-meter South Pole Telescope (SPT). The SPT-3G receiver will deliver a factor of ~20 improvement in mapping speed over the current receiver, SPTpol.
Ade, P. A. R., Ahmed, Z., Allen, S. W., Arnold, K., Austermann, J. E., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Cho, H. M., Ciocys, S. T., Cliche, J. F., Crawford, T. M., Cukierman, A., de Haan, T., Dobbs, M. A., Dutcher, D., Everett, W., Gilbert, A., Halverson, N. W., Hanson, D., Harrington, N. L., Hattori, K., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Irwin, K. D., Keisler, R., Knox, L., Kubik, D., Kuo, C. L., Lee, A. T., Leitch, E. M., Li, D., McDonald, M., Meyer, S. S., Montgomery, J., Myers, M., Natoli, T., Nguyen, H., Novosad, V., Padin, S., Pan, Z., Pearson, J., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Shirokoff, E., Simard, G., Smecher, G., Stark, A. A., Story, K., Suzuki, A., Thompson, K. L., Tucker, C., Vanderlinde, K., Vieira, J. D., Vikhlinin, A., Wang, G., Yefremenko, V., Yoon, K. W.   +63 more
core   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

The cosmic microwave background: observing directly the early universe

, 2012
The Cosmic Microwave Background (CMB) is a relict of the early universe. Its perfect 2.725K blackbody spectrum demonstrates that the universe underwent a hot, ionized early phase; its anisotropy (about 80 \mu K rms) provides strong evidence for the ...
de Bernardis, Paolo, Masi, Silvia
core   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source