Results 51 to 60 of about 9,598,617 (257)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
ENTREVISTA CON EDWIN GERMAN GARCIA ARTEAGA [PDF]
Gondola, 2011 Brief biography: Degree in Physics Teaching at National Pedagogical University, Colombia. Master in Physics Teaching at the National Pedagogical University, Colombia.
OLGA LUCIA CASTIBLANCO ABRIL
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Analysing pedagogical change: Physics teachers' responses to a new curriculum. [PDF]
, 2003 This paper describes teachers' attempts to implement the 1994 New Zealand physics curriculum in the first year of its introduction to secondary schools in 1998.
Ritchie, Garth +1 more
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CMS physics technical design report, volume II: Physics performance
, 2007 CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries.
Physics Collaboration +1 more
core +1 more source
Modern physics courses: Understanding the content taught in the U.S.
Physical Review Physics Education Research[This paper is part of the Focused Collection in Investigating and Improving Quantum Education through Research.] The modern physics course is a crucial gateway for physics majors as it provides an introduction to concepts beyond the scope of the K-12 ...
Alexis Buzzell +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A survey of psychological, motivational, family and perceptions of physics education factors that explain 15 year-old students’ aspirations to study post-compulsory physics in English schools [PDF]
, 2014 This paper investigates the factors that influence 15-year-old students’ intentions to study physics post-16, when it is no longer compulsory. The analysis is based on the year 10 (age, 15 years) responses of 5,034 students from 137 England schools as ...
Reiss, Michael +3 more
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