Results 191 to 200 of about 16,580 (214)

Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization

Investigative Ophthalmology and Visual Science, 2007
Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis. The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.C57BL/6 neonatal mice ...
Minako Kaido, Susumu Ishida, Hajime Shinoda   +2 more
exaly   +3 more sources

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Angiopoietin 2 Expression in the Retina: Upregulation During Physiologic and Pathologic Neovascularization

Journal of Cellular Physiology, 2000
Vascular development in the embryo requires coordinated signaling through several endothelial cell-specific receptors; however, it is not known whether this is also required later during retinal vascular development or as part of retinal neovascularization in adults.
Rupert W Strauss, Peter A Campochiaro, George Yancopoulos   +2 more
exaly   +5 more sources

Selective Suppression of Pathologic, but Not Physiologic, Retinal Neovascularization by Blocking the Angiotensin II Type 1 Receptor

Investigative Ophthalmology and Visual Science, 2005
To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization.C57BL/6 neonatal mice were reared in an 80% concentration of oxygen from postnatal day (P)7 to P12, followed by room-air breathing until P17, to induce ischemia-initiated ...
Minako Kaido, Susumu Ishida, Hajime Shinoda   +2 more
exaly   +3 more sources

Physiological function after middle cerebral artery occlusion in rabbits with neovascularization of the brain by transposed omentum

Neurosurgery, 1980
The effect of brain neovascularization by omental transposition on somatosensory evoked potentials and on regional cerebral blood flow (rCBF) measured by hydrogen clearance was evaluated in rabbits exposed to experimental ischemia after occlusion of the middle cerebral artery (MCA).
P L, DeRiu, A, Rocca, A, Falzoi, M, Carai, L, Papavero   +4 more
openaire   +2 more sources

Restoring Physiologic Barriers Against Neovascular Invasion

2014
Age-related macular degeneration remains to be a major cause of irreversible blindness in the world. In this disease, neovascularization plays an important role in disease burden and progression. Current therapies focus on inhibition of neovascularization through suppression of the extracellular VEGF pathway.
Cecinio C. Ronquillo, Samuel F. Passi, Balamurali K. Ambati   +2 more
openaire   +1 more source

Pleiotropic Effects of YC-1 Selectively Inhibit Pathological Retinal Neovascularization and Promote Physiological Revascularization in a Mouse Model of Oxygen-Induced Retinopathy

Molecular Pharmacology, 2010
Vascular endothelial growth factor (VEGF) and inducible nitric-oxide synthase (iNOS) have been implicated in ischemia-induced retinal neovascularization. Retinal ischemia has been shown to induce VEGF and iNOS expression. It has been postulated that one of the crucial consequences of iNOS expression in the ischemic retina is the inhibition of ...
M, DeNiro, A, Al-Halafi, F H, Al-Mohanna, O, Alsmadi, F A, Al-Mohanna   +4 more
openaire   +2 more sources

The Impaired Hindlimb Revascularization of Id1+/−, Id3−/− Mutant Supports a Role for Bone-Marrow Derived Progenitor Cells in Physiologic Neovascularization

Journal of the American College of Surgeons, 2004
Abstract Introduction: Increasing evidence suggests the importance of bone-marrow derived progenitor cells in angiogenesis. However, the exact role of the progenitor cells in hindlimb revascularization is unknown. In order to determine if endothelial progenitor cells are necessary for hindlimb revascularization, we used Id1+/−, Id3−/− mutant mouse ...
Yuki Sakai, Darren Schneider
exaly   +2 more sources

AS-040: Study of Dynamics of Endothelial Progenitor Cells Induced by Physiological Ischemia Training on Neovascularization

The American Journal of Cardiology, 2012
Chunxiao Wan, Jianan Li
openaire   +1 more source

Endothelial Cell Derived Stromal-Derived Factor-1 (SDF-1) Regulates Neovascularization and Fibroblast Physiology in Response to Ischemia

Journal of the American College of Surgeons, 2014
Zeshaan N. Maan, Alexander J. Whittam, Dominik Duscher, Michael S. Hu, Robert C. Rennert, Lauren H. Fischer, Graham G. Walmsley, Arnetha J. Whitmore, Michael T. Longaker, Geoffrey C. Gurtner   +9 more
openaire   +1 more source

Combined Physiologic and Excisional Therapies Improve Cancer-Related Lymphedema Outcomes

Ca-A Cancer Journal for Clinicians, 2018
Mike Fillon
exaly