Results 121 to 130 of about 4,767,765 (294)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Secular Trends in Physiological Capital: Implications for Equity in Health Care [PDF]

Over the past three centuries there has been a rapid accumulation of physiological capital in OECD countries. Enhanced physiological capital is tied to long-term reduction in environmental hazards and to the conquest of chronic malnutrition.
Robert W. Fogel
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Physiological and Transcriptome Analysis of Drought-Tolerant Mutant ds-1 of Blue Fescue (Festuca glauca) Under Drought Stress

International Journal of Plant Biology
Blue fescue (Festuca glauca) is a widely used ornamental grass worldwide. Drought is an important limiting factor for the growth and development of blue fescue; therefore, cultivating new strains of blue fescue with a strong drought tolerance is of great
Yong Zhang, Peng Han, Xuefeng Xiao, Wei Chen, Hang Liu, Hengfeng Zhang, Lu Xu   +6 more
doaj   +1 more source

Subminiature biotelemetry unit permits remote physiological investigations [PDF]

, 1964
A subminiature biotelemetry transmitter permits the measurement of biopotential response in humans or animals to controlled environmental stimuli without discomfort while engaged in normal ...

core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Clinical application of abdominal breathing training and evaluation of physical and mental benefits in anxiety patients

Frontiers in Psychology
BackgroundAnxiety disorders represent highly prevalent mental health conditions globally (lifetime prevalence: ~7–14%). Current pharmacological treatments carry risks of dependence and metabolic side effects, while psychological therapies face ...
Jiajin Chai, Shikun Li, Li He, Jiayuan Yang, Ting Wu, Kunyang Ou, Xichen Chen, Kaicheng Ma, Shouping Zhao   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effects of Non-Steady-State Noise on Pain, Anxiety and Stress Indicators in Patients Waiting for Coronary Angiography

Noise and Health
Objective: To investigate the effect of non-steady-state noise on pain, anxiety and stress levels in patients waiting for coronary angiography. Methods: A retrospective analysis was conducted on the clinical records of 310 patients who had undergone ...
Tong Sun, Xintao Li, Minna Fan
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source