Results 131 to 140 of about 331,675 (261)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Physiological adaptation during heart rate variability biofeedback in young adults: A survival analysis in high-stress academic environments. [PDF]

Physiol Rep
Panayotova G, Velikova M.
europepmc   +1 more source

Physiological Adaptation and Plant Distribution along a Steep Hydrological Gradient. [PDF]

Plants (Basel), 2022
Sand-Jensen K, Borum J, Møller CL, Baastrup-Spohr L.   +3 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications. [PDF]

Sports (Basel)
Fuentes-Barría H, Aguilera-Eguía R, Alarcón-Rivera M, Angarita-Davila L, Pena E, El Alam S, Flores-Fernández C.   +6 more
europepmc   +1 more source

Hypophysial angiogenesis decodes annual time and underlies physiological adaptation to seasonal changes in the environment. [PDF]

J Exp Zool A Ecol Integr Physiol, 2022
Tortonese DJ.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Cold exposure and the cardiovascular system: from physiological adaptation to pathological risk. [PDF]

Front Physiol
Li Y, Wu J, Xu Y, Dong J, Xing B, Wang Y, Zhou Z, Sun B, Li J, Yu L, Wang H.   +10 more
europepmc   +1 more source

History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure. [PDF]

Elife, 2022
Koganezawa Y, Umetani M, Sato M, Wakamoto Y.   +3 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source