Results 121 to 130 of about 1,699,941 (300)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of low nitrogen resistance of Avena sativa germplasm during the seed germination period

Heliyon
Nitrogen (N) plays a crucial role in forage yield. However, excessive application of N fertilizers in agricultural production not only increases the production cost but also leads to serious environmental problems.
Jing Pan, Zeliang Ju, Xiang Ma, Lianxue Duan, Zhifeng Jia   +4 more
doaj   +1 more source

Neurophysiological Assessment of Affective Experience [PDF]

, 2009
In the field of Affective Computing the affective experience (AX) of the user during the interaction with computers is of great interest. The automatic recognition of the affective state, or emotion, of the user is one of the big challenges.
Mühl, Christian
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Does social and emotional learning intervention influence physiological and biological indicators? A systematic literature review of universal and targeted programs in Pre-K to grade 12

Social and Emotional Learning: Research, Practice, and Policy
The effectiveness of Social and Emotional Learning (SEL) programs on child outcomes has been firmly established through student self-reporting, teacher and caregiver questionnaires, and direct assessment via performance tasks.
Claire Blewitt, Heather Morris, Yihan Sun, Michelle Gooey, Hannah Kirk, Heidi Bergmeier, Helen Skouteris   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Comparison of Physiological Stress Indices in Anesthetized and Manually Restrained Leopard Sharks, Triakis semifasciata

Biology
Background: Leopard sharks (Triakis semifasciata) are abundant, coastal, eastern Pacific, mesopredatory sharks and are frequently managed in aquariums and zoos.
Meghan M. Holst, Catharine J. Wheaton, Alexandra N. Schoen, Jill V. Spangenberg, Kevin T. McEligot, Melissa L. Schouest, Charlene M. Burns, Natalie D. Mylniczenko   +7 more
doaj   +1 more source

Physiological Assessment [PDF]

Journal of the Royal Society of Medicine, 1978
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comprehensive Systematic Literature Review on Cognitive Workload: Trends on Methods, Technologies and Case Studies

IET Collaborative Intelligent Manufacturing
Cognitive workload (CWL) assessment has gained increasing importance in Industry 4.0 and 5.0 settings where human–machine interactions are becoming more complex.
Andrea Lucchese, Antonio Padovano, Francesco Facchini   +2 more
doaj   +1 more source