Results 201 to 210 of about 1,699,941 (300)

Non-invasive physiological assessment of coronary artery obstruction on coronary computed tomography angiography. [PDF]

Neth Heart J
Becker LM, Peper J, van Nes SH, van Es HW, Sjauw KD, van de Hoef TP, Leiner T, Swaans MJ.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Noninvasive Coronary Physiological Assessment Derived From Computed Tomography. [PDF]

J Soc Cardiovasc Angiogr Interv
Yang S, Koo BK.
europepmc   +1 more source

A Multi-Mode System for Myocardial Functional and Physiological Assessment during Ex Situ Heart Perfusion. [PDF]

J Extra Corpor Technol, 2020
Duignan T, Guariento A, Doulamis IP, Kido T, Regan WL, Saeed M, Hoganson DM, Emani SM, Del Nido PJ, McCully JD, Matte GS.   +10 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

A physiological assessment of patient pain during surgery with wide-awake local anesthesia. [PDF]

J Orthop, 2020
MacNeill AL, Mayich DJ.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Physiological assessment of a 16 day, 4385 km ultra-endurance mountain bike race: A case study. [PDF]

Exp Physiol
Hyldahl RD, Gifford JR, Davidson LE, Hancock CR, Hafen PS, Parcell AC, Mack GW.   +6 more
europepmc   +1 more source

Anatomical and physiological assessment of a symptomatic anomalous origin of the right coronary artery from the pulmonary artery by noninvasive imaging examinations. [PDF]

J Cardiol Cases, 2020
Nishino S, Watanabe N, Komatsu M, Yano M, Shibata Y.   +4 more
europepmc   +1 more source