Results 81 to 90 of about 1,699,941 (300)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Use of a mobile platform for assessing urban heat stress in Rotterdam [PDF]

, 2010
In this study, an assessment of the intensity of the urban heat island (UHI) in Rotterdam was carried out using an innovative mobile bio-meteorological measuring platform mounted on a cargo bicycle.
Elbers, J.A., Heusinkveld, B.G., Holtslag, A.A.M., Hove, L.W.A., van, Jacobs, C.M.J., Moors, E.J., Steeneveld, G.J.   +6 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Visual information transfer. 1: Assessment of specific information needs. 2: The effects of degraded motion feedback. 3: Parameters of appropriate instrument scanning behavior [PDF]

Pilot and flight crew assessment of visually displayed information is examined as well as the effects of degraded and uncorrected motion feedback, and instrument scanning efficiency by the pilot.
Coates, G. D., Comstock, J. R., Jr., Kirby, R. H.   +2 more
core   +1 more source

INTERPERSONAL PHYSIOLOGY: ASSESSING INTERPERSONAL RELATIONSHIPS THROUGH PHYSIOLOGY

, 2020
Interpersonal physiology is the study of relationships between people’s physiological activates during social interactions. Converging evidence indicates that interdependencies develop between peoples’ autonomic systems, and can be indicative of psychosocial constructs such as empathy and attachment.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Dynamic filtering of static dipoles in magnetoencephalography [PDF]

, 2013
We consider the problem of estimating neural activity from measurements of the magnetic fields recorded by magnetoencephalography. We exploit the temporal structure of the problem and model the neural current as a collection of evolving current ...
Aston, John A. D., Johansen, Adam M., Kendall, W. S., Nichols, Thomas E., Sorrentino, Alberto   +4 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparative algological and bacteriological examinations on biofilms developed on different substrata in a shallow soda lake [PDF]

, 2008
According to the European Water Framework Directives, benthic diatoms of lakes are a tool for ecological status assessment. In this study, we followed an integrative sample analysis approach, in order to find an appropriate substratum for the water ...
A Cattaneo, A Cattaneo, A Poulicková, A. K. Borsodi, AS Rosemarin, B Massieux, C Schnitchen, CE Christie, D Eminson, European Parliament, G. Várbíró, Gy. Záray, H Utermöhl, J Podani, J Preston-Mafham, J Seele, J Tison, JA Grimes, JL Garland, JL Garland, JM Burkholder, JWG Lund, K Kralj, K Kröpfl, K. T. Kiss, K. É. Szabó, L King, P. Vladár, RG Wetzel, S Blanco, T Kohonen, U Anthoni, YS Park, É Ács, É Ács, É. Kiss, Éva Ács   +36 more
core   +1 more source