Results 81 to 90 of about 1,047,266 (265)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Differential physiological and photosynthetic responses of two populations of Astragalus tibetanus to NaCl stress

Frontiers in Agronomy
ObjectiveThis study investigated the influence of NaCl stress on the physiological and photosynthetic performance of Astragalus tibetanus Benth. Growth responses, osmotic adjustment, antioxidant activity, and photosynthetic inhibition were assessed at ...
Wang Jing, Zhao Xiao-Lin, Wang Yu-Qing, Liu Yue-Han, Li Pei-Ying, Tian Xin-Chun, Ma Song-Mei, Zhang Yun-Ling, Zhang Yun-Ling   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Public Sector’s Role Towards Sustainable Agricultural Economy and Rural Development: Techno-economic Feasibility Analysis of Hybrid Paddy Production

Journal of Agricultural Sciences
Rice is the major food crop and a significant source of foreign exchange of Pakistan. In order to meet food demands, high quality varieties of rice, including early and late maturing varieties, as well as hybrid and conventional rice varieties must be ...
Rana Shahzad Noor, Sidra Fatima, Muhammad Aali Misaal, Waqar Ahmed, Sher Abbas   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Revealing the Peculiarities of Female Students’ Physiological Characteristics with Different Somatotypes in the Absence of Compulsory Physical Activity at University

Physical Education Theory and Methodology
Objectives. The purpose of the study was to determine the parameters of female students’ physiological characteristics with different somatotypes, which they achieved by exercising outside the university due to COVID-19 quarantine and air raids during ...
Volodymyr Banakh, Gennadii Iedynak, Lesia Galamanzhuk, Oksana Blavt, Mykhailo Huska, Oleh Hrebik, Vitalii Dmytruk, Volodymyr Kovalchuk   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effects of three kinds of growth regulators on flowering and branch physiological characteristics of Paeonia rockii

Xibei zhiwu xuebao
[Objective] The study aims to explore the effects of three kinds of growth regulators on the flowering and branch physiological characteristics of Paeonia rockii and to provide theoretical basis for the chemical regulation of flowering traits of P ...
LIU Jiamiao, TANG Hong, ZHU Jiachen, TAO Xuanlin, XUE Nana   +4 more
doaj   +1 more source