Results 101 to 110 of about 741,396 (300)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Functional and Psychiatric Correlates of Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder. [PDF]
, 2018 Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are common comorbid conditions that affect large segments of the population. Individuals with comorbid PTSD/AUD face greater clinical and functional stressors than those with diagnoses ...
Haller, Moira +3 more
core
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Negative Effects of Early English Education on Korean Children [PDF]
, 2018 It may be fairly said that most countries around the world are joining the English-speaking world since English became one of the popular languages. In this situation when the importance of English is emphasized, people’s reaction to and recognition of ...
Hwang, Saebyuk
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Evaluation of the effect of growing area and different directions of tree on physiological browning and some morphological traits of fruits in plum (Prunus saliciana cv. Shablon( [PDF]
فیزیولوژی محیطی گیاهی, 2019 Plum flesh browning is one of the most important disorders in Golestan. This research is aimed to evaluate the effects of climatic conditions on this disorder and other physiochemical traits of the fruit.
Seyyed Mojtaba Hosseini +2 more
doaj
Mapping pathological phenotypes in a mouse model of CDKL5 disorder.
PLoS ONE, 2014 Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome.
Elena Amendola +13 more
doaj +1 more source
Bearing witness: working with clients who have experienced trauma - considerations for a person-centered approach to counseling [PDF]
, 2007 This paper explores traumatic experience from both a cultural and neurophysiological perspective. An argument is developed to support and challenge the person-centered approach in working with clients who have experienced trauma.
Rutherford, Morna C.
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source