Results 71 to 80 of about 741,396 (300)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

MANAGEMENT OF TAPERING DISORDER IN COCONUT

CORD, 1994
The tapering stem wilt of coconut was amply proven to be a physiological disorder, with relevance to physiological and bio chemical investigations of the 14th frond analysis.
Kamala Thirumalaiswamy, H. Vijayaraghavan, M.A.J.R. Savery   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pulverização de fontes de cálcio em pré-colheita para o controle de "bitter pit" em maçãs 'Catarina' Preharvest spraying with commercial sources of calcium for bitter pit control in 'Catarina' apples

Revista Brasileira de Fruticultura, 2011
Este trabalho teve como objetivo avaliar os efeitos de fontes de cálcio (Ca), aplicadas em pré-colheita, no controle de "bitter pit" e na qualidade físico-química de maçãs 'Catarina'.
José Masanori Katsurayama, Cassandro Vidal Talamini do Amarante, Cristiano André Steffens, Adilson José Pereira   +3 more
doaj  

Childhood anxiety: how schools identify, assess, provide resources to and refer students with anxiety [PDF]

, 2009
Includes bibliographical ...
Woodie, Karen L.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Predição de "bitter pit" em maçãs 'gala' Por meio da infiltração dos frutos com magnésio Prediction of bitter pit in 'gala'apples by means of fruit infiltration with magnesium

Revista Brasileira de Fruticultura, 2009
O "bitter pit" é considerado um dos principais distúrbios fisiológicos pós-colheita que ocorrem em maçãs. A análise nutricional dos frutos (concentrações de Ca, Mg, K e N), normalmente utilizada na avaliação do risco de ocorrência de "bitter pit ...
Cassandro Vidal Talamini do Amarante, Paulo Roberto Ernani, Cristiano André Steffens   +2 more
doaj   +1 more source

Out of the Frying Pan, Into the Fire: Mixed Affective Reactions to Social Proximity in Borderline and Avoidant Personality Disorders in Daily Life

, 2014
Social proximity typically helps individuals meet their belongingness needs, but several forms of psychopathology, including borderline and avoidant personality disorders (BPD and APD, respectively) are characterized by social difficulties.
Berenson, Kathy R., Downey, Geraldine, Gadassi, Reuma, Rafaeli, Eshkol, Snir, Avigal   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Persons Versus Brains: Biological Intelligence in Human Organisms [PDF]

, 2001
I go deep into the biology of the human organism to argue that the psychological features and functions of persons are realized by cellular and molecular parallel distributed processing networks dispersed throughout the whole body.
Steinhart, E.
core