Results 251 to 260 of about 511,607 (303)

Food effects on gastrointestinal physiology and drug absorption

Drug Metabolism and Pharmacokinetics, 2023
Food ingestion affects the oral absorption of many drugs in humans. In this review article, we summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo performance of orally administered solid dosage forms in fasted and fed states in humans.
Atsushi Kambayashi, Yoshiyuki Shirasaka
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Effect of some physiologically important drugs on the skin impedance

Medical & Biological Engineering & Computing, 1981
The impedance of rabbit skin has been measured in the frequency range 1–60 kHz using a simple a.c. bridge method and stainless steel electrodes. The effect of four important drugs, namely, adrenaline, noradrenaline, atropine and histamine, has been examined. It was found that all these drugs produced a decrease in the skin impedance in varying degrees,
J, Behari, D V, Rai
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Acute behavioral and physiological effects of modafinil in drug abusers

Behavioural Pharmacology, 2002
Modafinil, a novel stimulant, is effective in the treatment of excessive daytime sleepiness associated with narcolepsy. It is biochemically and pharmacologically distinct from prototypical stimulants such as D-amphetamine, cocaine, and methylphenidate. The present experiment was designed to assess the acute behavioral effects of oral modafinil, cocaine,
C R, Rush, T H, Kelly, L R, Hays, R W, Baker, A F, Wooten   +4 more
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Physiologic changes in pregnancy and their effect on drug disposition

Seminars in Perinatology, 2001
Changes in maternal physiology occur normally during pregnancy and have the potential to alter the absorption, distribution, and elimination of drugs used therapeutically in pregnant women. These physiologic changes include: plasma volume expansion and increases in extracellular fluid space and total body water; decreased plasma albumin concentration ...
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Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis [PDF]

The Lancet Child and Adolescent Health
BACKGROUND The degree of physiological responses to individual antipsychotic drugs is unclear in children and adolescents. With network meta-analysis, we aimed to investigate the effects of various antipsychotic medications on physiological variables ...
Kyriakopoulos, Marinos, Salazar-de-Pablo, Gonzalo, McCutcheon, Robert A, Correll, Christoph U, Watson, Cameron J., Gilbert, Barnabas J., D'Ambrosio, Enrico, Howes, Oliver D, Fanshawe, Jack B, Philip, Aaron, Mancini, Valentina, Cipriani, Andrea, Efthimiou, Orestis, Martini, Maria Giulia, McCutcheon, Robert A.; id_orcid, Pillinger, Toby; id_orcid, Fanshawe, Jack B., Gilbert, Barnabas J, Telesia, Laurence, Howes, Oliver D., Siskind, Dan, Watson, Cameron J, Correll, Christoph U., Rogdaki, Maria, Carr, Richard, Pillinger, Toby   +25 more
exaly   +2 more sources

Physiological and Laboratory Markers of Drug Effect

2007
This chapter focuses on physiological and laboratory markers of drug effect. The selection and measurement of relevant drug effects are important parts of clinical pharmacology. The biomarkers have served as surrogate endpoints and have provided the basis for regulatory approval of new drugs.
ARTHUR J. ATKINSON, PAUL ROLAN
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THE EFFECT OF SELENIUM-CONTAINING DRUGS ON THE PHYSIOLOGICAL STATUS OF BROILER CHICKENS

SCIENTIFIC LIFE, 2023
The use of selenium-containing preparations "E-selenium", "Selplex" and "LovitVA + SE" in the diet of broiler chickens stimulates humoral non-specific protective factors, an increase in the number of erythrocytes, total protein, albumin, vitamin E, carotene and allows you to get high-quality products of meat origin from broiler chickens.
Ekaterina Nikolaevna Kudryavtseva, Marat Valerievich Ostrovsky, Evgeny Alexandrovich Yushkovsky, Pavel Igorevich Pakhomov, Oleg Yurievich Chernykh, Alexander Alekseevich Shevchenko   +5 more
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Animal models to investigate drug effects on coronary physiology

Drug Development Research, 1986
AbstractCoronary blood flow is regulated by local intrinsic mechanisms according to the oxygen need of the myocardium, but the coronary circulation is also modulated by nervous, humoral, and extravascular influences. Therefore, any method used to study drug effects on the coronary circulation must take into account not only the direct effects of the ...
Carl E. Jones, Patricia A. Gwirtz
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Physiological Modeling of Concentration-Effect Relationship for Nondepolarizing Neuromuscular Blocking Drugs

2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020
This paper reports modeling of physiological processes of neuromuscular transmission considering effects of nondepolarizing neuromuscualr blocking drugs (NDNBs) used during general anesthesia. NDNBs are considered to act by interacting with acetylcohine receptors located at pre- and post-junctional sites.
Hikaru Hoshino, Eiko Furutani, Tomonori Sugawara, Toshihiro Takeda, Yoshiharu Sawanobori, Gotaro Shirakami   +5 more
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Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology

Clinical Reviews in Bone and Mineral Metabolism, 2007
Drugs may affect bone turnover and density in many ways. However, the disease for which the drugs are administered may also contribute to bone loss. Infection with human immunodeficiency virus leads to a loss of bone mineral, while treatment with highly active antiretroviral therapy does not seem to contribute to further bone loss.
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