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Engineering human Gut-on-a-Chip culturomics for predictive pharmacomicrobiomics of first-pass metabolism. [PDF]
NPJ Biomed InnovNagao I, Kim HJ.
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Special Issue "Novel Targeted Therapies and Drugs in Cancer". [PDF]
Int J Mol SciVietri MT.
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Predicting the physiological effects of multiple drugs using electronic health record
Computers in Biology and MedicineABSTRACT Various computational models have been developed to understand the physiological effects of drug-drug interactions, which can contribute to more effective drug treatments. However, they mostly focus on interactions of only two drugs, and do not consider the patient information.
Hyun Uk Kim +2 more
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Food effects on gastrointestinal physiology and drug absorption
Drug Metabolism and Pharmacokinetics, 2023Food ingestion affects the oral absorption of many drugs in humans. In this review article, we summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo performance of orally administered solid dosage forms in fasted and fed states in humans.
Atsushi Kambayashi, Yoshiyuki Shirasaka
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Effect of some physiologically important drugs on the skin impedance
Medical & Biological Engineering & Computing, 1981The impedance of rabbit skin has been measured in the frequency range 1–60 kHz using a simple a.c. bridge method and stainless steel electrodes. The effect of four important drugs, namely, adrenaline, noradrenaline, atropine and histamine, has been examined. It was found that all these drugs produced a decrease in the skin impedance in varying degrees,
J, Behari, D V, Rai
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Acute behavioral and physiological effects of modafinil in drug abusers
Behavioural Pharmacology, 2002Modafinil, a novel stimulant, is effective in the treatment of excessive daytime sleepiness associated with narcolepsy. It is biochemically and pharmacologically distinct from prototypical stimulants such as D-amphetamine, cocaine, and methylphenidate. The present experiment was designed to assess the acute behavioral effects of oral modafinil, cocaine,
C R, Rush +4 more
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Physiologic changes in pregnancy and their effect on drug disposition
Seminars in Perinatology, 2001Changes in maternal physiology occur normally during pregnancy and have the potential to alter the absorption, distribution, and elimination of drugs used therapeutically in pregnant women. These physiologic changes include: plasma volume expansion and increases in extracellular fluid space and total body water; decreased plasma albumin concentration ...
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THE EFFECT OF SELENIUM-CONTAINING DRUGS ON THE PHYSIOLOGICAL STATUS OF BROILER CHICKENS
SCIENTIFIC LIFE, 2023The use of selenium-containing preparations "E-selenium", "Selplex" and "LovitVA + SE" in the diet of broiler chickens stimulates humoral non-specific protective factors, an increase in the number of erythrocytes, total protein, albumin, vitamin E, carotene and allows you to get high-quality products of meat origin from broiler chickens.
Ekaterina Nikolaevna Kudryavtseva +5 more
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Physiological and Laboratory Markers of Drug Effect
2007This chapter focuses on physiological and laboratory markers of drug effect. The selection and measurement of relevant drug effects are important parts of clinical pharmacology. The biomarkers have served as surrogate endpoints and have provided the basis for regulatory approval of new drugs.
ARTHUR J. ATKINSON, PAUL ROLAN
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