Results 261 to 270 of about 511,607 (303)
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Clinical Pharmacokinetics, 1998
There is an increasing awareness that the exclusion of women from clinical trials may lead to inaccurate application of drug therapy in women. Gender and estrus cycle differences in the pharmacokinetics and pharmacodynamics of drugs in animals have been appreciated for over 60 years, but investigation into these differences in humans has only recently ...
A D, Kashuba, A N, Nafziger
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There is an increasing awareness that the exclusion of women from clinical trials may lead to inaccurate application of drug therapy in women. Gender and estrus cycle differences in the pharmacokinetics and pharmacodynamics of drugs in animals have been appreciated for over 60 years, but investigation into these differences in humans has only recently ...
A D, Kashuba, A N, Nafziger
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Basic concepts of ion channel physiology and anaesthetic drug effects
European Journal of Anaesthesiology, 2003Ion channels regulate a diversity of physiological functions such as neuronal signalling, cardiac excitability and immune cell response. All of these systems may be affected during the conduct of general as well as local anaesthesia. Thus, the investigation of anaesthetic action on ion channels has become the focus of an increasing number of laboratory
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[Effect of some drugs on physiological icterus in the newborn].
Minerva ginecologica, 1992The Authors have correlated neonatal jaundice with the administration of oxytocin and prifinium bromide to the mother either alone or in association during labour. The percentage of neonatal jaundice in women treated with ritodrine hydrochloride during the second and third trimester of pregnancy was also calculated.
S, Rugolo +5 more
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Effect of pH and Buffer Capacity of Physiological Bicarbonate Buffer on Precipitation of Drugs
Molecular PharmaceuticsThe purpose of this study was to investigate the effect of the pH and buffer capacity (β) of physiological bicarbonate buffer solutions (BCB) on drug precipitation. The precipitation profiles of poorly soluble drugs in BCB were evaluated by using a pH-shift precipitation test. Phosphate buffer solutions (PPB) were used for comparison. Two weakly acidic
Hibiki Yamamoto, Kiyohiko Sugano
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Effects of Some Drugs on the Physiological Changes during Exercise in the Horse
Equine Veterinary Journal, 1975SUMMARY Exercise initiates cardiovascular and respiratory responses and also results in a series of biochemical changes. In the evaluation of the effects of drugs on speed and performance, horses have been subjected to a number of standardised exercise tests in which an assessment of cardiac and respiratory ...
J. SANFORD, M. M. AITKEN
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Effect of propranolol on drug-induced and physiological glycogenolysis in the liver.
Arzneimittel-Forschung, 1979The beta-adrenergic blocking agent propranolol had in itself no notable influence on the blood glucose level in rats, but in combination with chlorpropamide it considerably delayed and enhanced the hypoglycaemic and liver glycogenolysis depressing actions of chlorpropamide. This effect was still more pronounced when the rats were treated in addition to
G, Pogátsa, E, Dubecz
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Drug and Alcohol Dependence, 2005
Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S. over the last several years, we sought to profile its subjective, psychomotor, and physiological effects in recreational drug users.
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Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S. over the last several years, we sought to profile its subjective, psychomotor, and physiological effects in recreational drug users.
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Physiological Effects of Thiouracil and Similar Drugs on Sheep
Journal of Animal Science, 1950E R, BARRICK, F N, ANDREWS, W M, BEESON
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The physiology of cervical ripening and cervical dilatation and the effect of abortifacient drugs.
Bailliere's clinical obstetrics and gynaecology, 1990The mechanical properties of the human uterine cervix are determined mainly by the connective tissue component, whereas it is doubtful whether the scanty smooth muscle component is of any physiological importance. Histological and biochemical analyses reveal a fibrous connective tissue similar to that found in skin and tendon.
N, Uldbjerg, U, Ulmsten
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Effects of Drugs and Physiological Factors in the Disposition of Catecholamines in Blood Vessels
Pharmacological Reviews, 1972S, Spector, J, Tarver, B, Berkowitz
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