Results 261 to 270 of about 166,736,405 (308)
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Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology
Clinical Reviews in Bone and Mineral Metabolism, 2007Drugs may affect bone turnover and density in many ways. However, the disease for which the drugs are administered may also contribute to bone loss. Infection with human immunodeficiency virus leads to a loss of bone mineral, while treatment with highly active antiretroviral therapy does not seem to contribute to further bone loss.
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Animal models to investigate drug effects on coronary physiology
Drug Development Research, 1986AbstractCoronary blood flow is regulated by local intrinsic mechanisms according to the oxygen need of the myocardium, but the coronary circulation is also modulated by nervous, humoral, and extravascular influences. Therefore, any method used to study drug effects on the coronary circulation must take into account not only the direct effects of the ...
Carl E. Jones, Patricia A. Gwirtz
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2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020
This paper reports modeling of physiological processes of neuromuscular transmission considering effects of nondepolarizing neuromuscualr blocking drugs (NDNBs) used during general anesthesia. NDNBs are considered to act by interacting with acetylcohine receptors located at pre- and post-junctional sites.
Hikaru Hoshino +5 more
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This paper reports modeling of physiological processes of neuromuscular transmission considering effects of nondepolarizing neuromuscualr blocking drugs (NDNBs) used during general anesthesia. NDNBs are considered to act by interacting with acetylcohine receptors located at pre- and post-junctional sites.
Hikaru Hoshino +5 more
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Basic concepts of ion channel physiology and anaesthetic drug effects
European Journal of Anaesthesiology, 2003Ion channels regulate a diversity of physiological functions such as neuronal signalling, cardiac excitability and immune cell response. All of these systems may be affected during the conduct of general as well as local anaesthesia. Thus, the investigation of anaesthetic action on ion channels has become the focus of an increasing number of laboratory
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Clinical Pharmacokinetics, 1998
There is an increasing awareness that the exclusion of women from clinical trials may lead to inaccurate application of drug therapy in women. Gender and estrus cycle differences in the pharmacokinetics and pharmacodynamics of drugs in animals have been appreciated for over 60 years, but investigation into these differences in humans has only recently ...
A D, Kashuba, A N, Nafziger
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There is an increasing awareness that the exclusion of women from clinical trials may lead to inaccurate application of drug therapy in women. Gender and estrus cycle differences in the pharmacokinetics and pharmacodynamics of drugs in animals have been appreciated for over 60 years, but investigation into these differences in humans has only recently ...
A D, Kashuba, A N, Nafziger
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[Effect of some drugs on physiological icterus in the newborn].
Minerva ginecologica, 1992The Authors have correlated neonatal jaundice with the administration of oxytocin and prifinium bromide to the mother either alone or in association during labour. The percentage of neonatal jaundice in women treated with ritodrine hydrochloride during the second and third trimester of pregnancy was also calculated.
S, Rugolo +5 more
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The physiology of cervical ripening and cervical dilatation and the effect of abortifacient drugs.
Bailliere's clinical obstetrics and gynaecology, 1990Udgivelsesdato: 1990 ...
Uldbjerg, N; id_orcid 0000-0002-6449-6426 +1 more
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Effects of Some Drugs on the Physiological Changes during Exercise in the Horse
Equine Veterinary Journal, 1975SUMMARY Exercise initiates cardiovascular and respiratory responses and also results in a series of biochemical changes. In the evaluation of the effects of drugs on speed and performance, horses have been subjected to a number of standardised exercise tests in which an assessment of cardiac and respiratory ...
J. SANFORD, M. M. AITKEN
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Effect of pH and Buffer Capacity of Physiological Bicarbonate Buffer on Precipitation of Drugs
Molecular PharmaceuticsThe purpose of this study was to investigate the effect of the pH and buffer capacity (β) of physiological bicarbonate buffer solutions (BCB) on drug precipitation. The precipitation profiles of poorly soluble drugs in BCB were evaluated by using a pH-shift precipitation test. Phosphate buffer solutions (PPB) were used for comparison. Two weakly acidic
Hibiki Yamamoto, Kiyohiko Sugano
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Drug and Alcohol Dependence, 2005
Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S. over the last several years, we sought to profile its subjective, psychomotor, and physiological effects in recreational drug users.
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Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S. over the last several years, we sought to profile its subjective, psychomotor, and physiological effects in recreational drug users.
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