Results 91 to 100 of about 6,434,349 (320)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms

Frontiers in Bioengineering and Biotechnology, 2020
Lung exposure to inhaled particulate matter (PM) is known to injure the airway epithelium via inflammation, a phenomenon linked to increased levels of global morbidity and mortality.
Shani Elias-Kirma, Arbel Artzy-Schnirman, Prashant Das, Metar Heller-Algazi, Netanel Korin, Josué Sznitman   +5 more
doaj   +1 more source

Simulation of blood flow through an artificial heart [PDF]

A numerical simulation of the incompressible viscous flow through a prosthetic tilting disk heart valve is presented in order to demonstrate the current capability to model unsteady flows with moving boundaries.
Chang, I-Dee, Kiris, Cetin, Kwak, Dochan, Rogers, Stuart E.   +3 more
core   +1 more source

Influence of Slippery Pacemaker Leads on Lead-Induced Venous Occlusion [PDF]

, 2017
The use of medical devices such as pacemakers and implantable cardiac defibrillators have become commonplace to treat arrhythmias. Pacing leads with electrodes are used to send electrical pulses to the heart to treat either abnormally slow heart rates ...
Bhatia, Sagar
core   +1 more source

Multiscale modelling of fluid and solute transport in soft tissues and microvessels [PDF]

, 2010
This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several ...
Lu, Yiling, Wang, Wen
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Peristaltic Pumping of Blood Through Small Vessels of Varying Cross-section

, 2012
The paper is devoted to a study of the peristaltic motion of blood in the micro-circulatory system. The vessel is considered to be of varying cross-section. The progressive peristaltic waves are taken to be of sinusoidal nature. Blood is considered to be
Anand, Barbee, Bhargava, Blair, Bohme, Brassur, Bugliarello, Chakraborty, Charm, Charm, Chien, Fung, Fung, Gupta, Guyton, Hayat, Higdon, Huang, J. C. Misra, Jaffrin, Jimenez-Lozano, Jimenez-Lozano, Kwack, Lardner, Lee, Li, Maiti, Maiti, Malek, Masud, Merrill, Mishra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Pozrikidis, Provost, Rand, S. Maiti, Selvarajan, Shapiro, Srivastava, Srivastava, Srivastava, Takabatake, Usha, Usha, Wang, White, Wiederhielm, Wiedman, Xue, Yaniv   +61 more
core   +1 more source

Hawaiian Picture‐Winged Drosophila Exhibit Adaptive Population Divergence along a Narrow Climatic Gradient on Hawaii Island [PDF]

, 2019
1. Anthropogenic influences on global processes and climatic conditions are increasingly affecting ecosystems throughout the world. 2. Hawaii Island’s native ecosystems are well studied and local long‐term climatic trends well documented, making these ...
Bellinger, M. Renee, Eldon, Jon, Price, Donald K.   +2 more
core   +2 more sources

Quantifying Food Web Flows Using Linear Inverse Models

Ecosystems, 2009
The quantitative mapping of food web flows based on empirical data is a crucial yet difficult task in ecology. The difficulty arises from the under-sampling of food webs, because most data sets are incomplete and uncertain.
D. Oevelen, K. V. D. Meersche, F. Meysman, K. Soetaert, J. Middelburg, A. Vézina   +5 more
semanticscholar   +1 more source