Results 61 to 70 of about 49,903 (309)

A Device for Automatically Measuring and Supervising the Critical Care Patient’S Urine Output

Sensors, 2010
Critical care units are equipped with commercial monitoring devices capable of sensing patients’ physiological parameters and supervising the achievement of the established therapeutic goals.
Roemi Fernández, Francisco Palacios, Teodor Akinfiev, Abraham Otero   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

GPR68 Senses Flow and Is Essential for Vascular Physiology [PDF]

Cell, 2018
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis.
Xu, Jie, Mathur, Jayanti, Vessières, Emilie, Hammack, Scott, Nonomura, Keiko, Favre, Julie, Grimaud, Linda, Petrus, Matt, Francisco, Allain, Li, Jingyuan, Lee, Van, Xiang, Fu-li, Mainquist, James K, Cahalan, Stuart M, Orth, Anthony P, Walker, John R, Ma, Shang, Lukacs, Viktor, Bordone, Laura, Bandell, Michael, Laffitte, Bryan, Xu, Yan, Chien, Shu, Henrion, Daniel, Patapoutian, Ardem   +24 more
openaire   +4 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Determinants of forced expiratory flows in newborn infants

, 1982
Maximal flows at functional residual capacity (VmaxFRC) from partial expiratory flow-volume (PEFV) curves (achieved with rapid compression of the chest) were obtained on 11 healthy newborn babies. Mean VmaxFRC, size corrected by dividing absolute values
S. Godfrey, L. I. Landau, I. Arad, L. M. Taussig   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Dynamic model of the lactating dairy cow metabolism

Animal, 2007
The whole-animal model described in this paper is intended to be a research model with an intermediary structure between sophisticated and simple cow models.
O. Martin, D. Sauvant
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms

Frontiers in Bioengineering and Biotechnology, 2020
Lung exposure to inhaled particulate matter (PM) is known to injure the airway epithelium via inflammation, a phenomenon linked to increased levels of global morbidity and mortality.
Shani Elias-Kirma, Arbel Artzy-Schnirman, Prashant Das, Metar Heller-Algazi, Netanel Korin, Josué Sznitman   +5 more
doaj   +1 more source