Results 91 to 100 of about 184,495 (261)

Endothelial cell dysfunction and targeted therapeutic drugs in sepsis

Heliyon
Sepsis is a life-threatening organ dysfunction caused by an abnormal host response to microbial infections. During its pathogenesis, vascular endothelial cells (ECs) play a pivotal role as essential components in maintaining microcirculatory homeostasis.
Kunwei Chen, Dongdong Wang, Minyue Qian, Mengcao Weng, Zhongteng Lu, Kai Zhang, Yue Jin   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Function and physiology : the concept of function in contemporary physiology

, 2021
This thesis proposes a theory of biological function which takes as a starting point the meaning given to it by physiology. The proposed theory is based on the following principles: (1) the notion of teleology has two dimensions which should be distinguished, its teleonomic dimension (goal-directiveness) on the one hand and its etiological dimension ...
openaire   +1 more source

Evaluation of the Thermophysiological Comfort Properties of Single-Knit Jersey Fabrics

Advances in Materials Science and Engineering
The thermal and physiological comfort of fabric has emerged as a priority over service life and perceived value in today’s apparel industry. The balance between thermal and physical sensations of fabrics profoundly influences consumer perceptions of ...
Derseh Yilie Limeneh, Kalavathy Rajan, Brendan Kelly, Addisu Ferede Tesema, Kelem Tiessasie Yilma, Noureddine Abidi, Zelalem Adane Alemar   +6 more
doaj   +1 more source

Characterization of cortical volume and whole-brain functional connectivity in Parkinson’s disease patients: a MRI study combined with physiological aging brain changes

Frontiers in Neuroscience
This study employed multiple MRI features to comprehensively evaluate the abnormalities in morphology, and functionality associated with Parkinson’s disease (PD) and distinguish them from normal physiological changes.
Shuaiwen Wang, Shuaiwen Wang, Shuaiwen Wang, Shuaiwen Wang, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Yanli Zhang, Yanli Zhang, Yanli Zhang, Yanli Zhang, Yulin Gao, Yulin Gao, Yulin Gao, Yulin Gao, Lubin Gou, Lubin Gou, Lubin Gou, Lubin Gou, Junqiang Lei, Junqiang Lei, Junqiang Lei, Junqiang Lei   +23 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis

Viruses
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T lymphocytes to eliminate virus-infected cells. Since T cell exhaustion
Valentina Casella, Paula Cebollada Rica, Jordi Argilaguet, Enric Vidal, María González-Cao, Roberto Güerri-Fernandez, Gennady Bocharov, Andreas Meyerhans   +7 more
doaj   +1 more source