Results 51 to 60 of about 818,500 (292)

Neural substrates of choking under pressure: A 7T-fMRI study

Neuroscience Research
Performance decrement under excessive psychological pressure is known as “choking,” yet its mechanisms and neural foundations remain underexplored. Hypothesizing that changes in the internal model could induce choking, we conducted a 7 T functional MRI ...
Kanae Ogasawara, Takahiko Koike, Masaki Fukunaga, Ayumi Yoshioka, Tetsuya Yamamoto, Norihiro Sadato   +5 more
doaj   +1 more source

Combining high-throughput imaging flow cytometry and deep learning for efficient species and life-cycle stage identification of phytoplankton

BMC Ecology, 2018
Background Phytoplankton species identification and counting is a crucial step of water quality assessment. Especially drinking water reservoirs, bathing and ballast water need to be regularly monitored for harmful species.
Susanne Dunker, David Boho, Jana Wäldchen, Patrick Mäder   +3 more
doaj   +1 more source

Cell-based sensors for quantifying the physiological impact of microsystems [PDF]

, 2010
2012 January 1Microsystems are increasingly used in the manipulation, patterning and sorting of cells. Critical to the widespread adoption of these new technologies is development of an understanding of their impact on cellular physiology.
A, Abravaya, Abravaya, Albrecht, Albrecht, Bevis, Burg, Chabert, Di Carlo, El-Ali, Feder, Fuhr, Gascoyne, Glasser, Gu, Joel Voldman, Khademhosseini, L, Laszlo, Lindquist, Liu, Matsue, Mitra, Molina, Morimoto, Onderwater, Parsell, Perlman, Rider, Salil P. Desai, Shaw, Suehiro, Taff, Tan, Vahey, Vasanawala, Wang, Wu, Zeng   +38 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Millisecond single-molecule localization microscopy combined with convolution analysis and automated image segmentation to determine protein concentrations in complexly structured, functional cells, one cell at a time [PDF]

, 2015
We present a single-molecule tool called the CoPro (Concentration of Proteins) method that uses millisecond imaging with convolution analysis, automated image segmentation and super-resolution localization microscopy to generate robust estimates for ...
Leake, Mark C., Wollman, Adam J. M.
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes [PDF]

, 2009
Central nervous processing of environmental stimuli requires integration of sensory information with ongoing autonomic control of cardiovascular function.
Critchley, Hugo D, Gray, Marcus A, Harrison, Neil A, Rylander, Karin, Wallin, B Gunnar   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interactions between visceral afferent signaling and stimulus processing [PDF]

, 2015
Visceral afferent signals to the brain influence thoughts, feelings and behaviour. Here we highlight the findings of a set of empirical investigations in humans concerning body-mind interaction that focus on how feedback from states of autonomic arousal ...
Anderson, Barrett, Bechara, Bechara, Boubela, Cannon, Cannon, Cantril, Clark, Critchley, Critchley, Critchley, Critchley, Critchley, Critchley, Critchley, Damasio, Damasio, Darwin, Donadio, Donadio, Dworkin, Edwards, Ekman, Ekman, Ekman, Feinstein, Garfinkel, Garfinkel, Gianaros, Gray, Gray, Gray, Gray, Gray, Hugo D. Critchley, James, Katkin, Katkin, Lacey, Lacey, Lange, Lange, LeDoux, Maranon, McIntyre, McIntyre, Medford, Nagai, Park, Paulus, Paulus, Pollatos, Rau, Santos, Sarah N. Garfinkel, Schachter, Schandry, Wager, Wallin, Whitehead, Wiens, Wild   +62 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source