Results 61 to 70 of about 4,628,531 (299)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Mobile distributed processing of physiological data [PDF]
, 2012 Physiological monitoring can be useful in a number of scenarios to evaluate or diagnose the status of individuals or groups, for health or mental reasons.
Lee, K. +5 more
core +1 more source
Economic integration in southeast Asia: The case of the ASEAN power grid [PDF]
, 2020 © 2020-Center for Economic Integration, Sejong Institution, Sejong University, All Rights Reserved. The Association of Southeast Asia Nations (ASEAN) Power Grid (APG) is an interesting case study on how and why beneficial economic integration may not ...
Yao, L, Shi, X
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Does physiological integration among intraclonal ramets of Iris pumila enhance stress tolerance in heterogeneous environments? [PDF]
Archives of Biological Sciences, 2014 We tested the hypothesis that sharing essential resources through interconnected ramets increases stress tolerance of a clonal plant in patchy environments.
Manitašević-Jovanović Sanja +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Effects of clonal fragmentation on Pyrrosia nuda depend on growth stages in a rubber plantation
Frontiers in Plant ScienceIntroductionClonal fragmentation helps to assess clonal plants' growth resilience to human and environmental disturbance. Although clonal integration in epiphytes in tropical rubber plantations is important to understand their role in enhancing ...
Xiaocheng Yu +19 more
doaj +1 more source
Frontiers in Human Neuroscience, 2014 Functional connectivity is of central importance in understanding brain function. For this purpose, multiple time series of electric cortical activity can be used for assessing the properties of a network: the strength, directionality, and spectral ...
Roberto D Pascual-Marqui +8 more
doaj +1 more source