Results 161 to 170 of about 7,343 (217)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

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The physiological functions of lymphangiocrine signals

Trends in Endocrinology & Metabolism, 2023
It has been demonstrated that the lymphatic system plays important roles in tissue development and the progress of diseases. Recent studies identified that lymphatic endothelial cells can secret many proteins with diverse functions. This article highlights the physiological significances of these lymphangiocrine signals in different tissues.
Cenxi Liu, Jin Li
openaire   +2 more sources

The redox signal: A physiological perspective

IUBMB Life, 2021
AbstractA signal in biology is any kind of coded message sent from one place in an organism to another place. Biology is rich in claims that reactive oxygen and nitrogen species transmit signals. Therefore, we define a “redox signal as an increase/decrease in the level of reactive species”.
Nikos V. Margaritelis, Panagiotis N. Chatzinikolaou, Alexandros N. Chatzinikolaou, Vassilis Paschalis, Anastasios A. Theodorou, Ioannis S. Vrabas, Antonios Kyparos, Michalis G. Nikolaidis   +7 more
openaire   +2 more sources

Causality in physiological signals

Physiological Measurement, 2016
Health is one of the most important non-material assets and thus also has an enormous influence on material values, since treating and preventing diseases is expensive. The number one cause of death worldwide today originates in cardiovascular diseases.
Müller, A., Kraemer, J., Penzel, T., Bonnemeier, H., Kurths, J., Wessel, N.   +5 more
openaire   +3 more sources

The Identification of Peaks in Physiological Signals

Computers and Biomedical Research, 1999
The identification of peaks is fundamental in the processing of physiological signals. For example, it is common to the analysis of electrocardiograms, electroencephalograms, sympathetic neuronal activity, pulse oximetry, respiratory movement, hormone pulse secretion, and even chromatography.
Bryan S. Todd, David C. Andrews
openaire   +2 more sources

PAK signalling in neuronal physiology

Cellular Signalling, 2009
Group I p21-activated kinases are a family of key effectors of Rac1 and Cdc42 and they regulate many aspects of cellular function, such as cytoskeleton dynamics, cell movement and cell migration, cell proliferation and differentiation, and gene expression. The three genes PAK1/2/3 are expressed in brain and recent evidence indicates their crucial roles
Kreis, Patricia, Barnier, Jean-Vianney
openaire   +2 more sources

Wnt Signaling: Physiology and Pathology

Growth Factors, 2004
Signaling by the Wnt family of secreted glycoproteins has been demonstrated to be essential both in normal embryonic development and in the pathogenesis of a variety of diseases, including cancer. This signaling pathway is exquisitely regulated by a large and complex array of proteins, which act as agonists or antagonists of signal transduction ...
Céline, Prunier, Barbara A, Hocevar, Philip H, Howe   +2 more
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Thrombopoietin Signalling in Physiology and Disease

Growth Factors, 2004
Thrombopoietin (TPO) is a key physiological regulator of steady-state megakaryocytopoiesis, the process of megakaryocyte production and maturation that ultimately results in the formation of platelets. Ten years have passed since the purification and cloning of TPO and extensive studies of the activities of recombinant forms of the cytokine, as well as
Brooke, Fishley, Warren S, Alexander
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Physiology and Mathematics of Myoelectric Signals

IEEE Transactions on Biomedical Engineering, 1979
The myoelectric (ME) signal is the electrical manifestation of the neuromuscular activation associated with a contracting muscle. It is an exceedingly complicated signal which is affected by the anatomical and physiological properties of muscles, the control scheme of the peripheral nervous system, as well as the characteristics of the instrumentation ...
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