Results 81 to 90 of about 6,025,139 (346)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review

Frontiers in Immunology
More than 20% of American adults live with a mental disorder, many of whom are treatment resistant or continue to experience symptoms. Other approaches are needed to improve mental health care, including prevention. The role of the microbiome has emerged
Alison Warren, Yvonne Nyavor, Aaron Beguelin, Leigh A. Frame   +3 more
doaj   +1 more source

Role of stress in progression of Migraine

International Journal of Endorsing Health Science Research, 2014
The mental and physiological stresses can be an important trigger of migraines & headaches. These strains act to enhance the progression of migraine that could be psychological, physiological stress, Environmental stress or Chemical stress.
Shamoon Noushad, Sadaf Ahmed, Huma Khalid, Rida Nasir, Ikram Tunio, Shaikh Tahir   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Approaches to modeling the development of physiological stress responsivity.

Psychophysiology, 2018
Influential biopsychosocial theories have proposed that some developmental periods in the lifespan are potential pivot points or opportunities for recalibration of stress response systems.
J. B. Hinnant, Lauren E. Philbrook, Stephen A. Erath, M. El-Sheikh   +3 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Association of Proteomics Changes with Al-Sensitive Root Zones in Switchgrass

Proteomes, 2018
In this paper, we report on aluminum (Al)-induced root proteomic changes in switchgrass. After growth in a hydroponic culture system supplemented with 400 μM of Al, plants began to show signs of physiological stress such as a reduction in photosynthetic ...
Mahesh Rangu, Zhujia Ye, Sarabjit Bhatti, Suping Zhou, Yong Yang, Tara Fish, Theodore W. Thannhauser   +6 more
doaj   +1 more source

Insights into the Physiological and Biochemical Impacts of Salt Stress on Plant Growth and Development

Agronomy, 2020
Climate change is causing soil salinization, resulting in crop losses throughout the world. The ability of plants to tolerate salt stress is determined by multiple biochemical and molecular pathways.
M. Shahid, A. Sarkhosh, N. Khan, R. Balal, Shahid Ali, Lorenzo Rossi, Celina Gómez, N. Mattson, W. Nasim, F. García-Sánchez   +9 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

O estresse do trabalhador de enfermagem: estudo em diferentes unidades de um hospital universitário [The stress of nursing workers: study in different units of a university hospital]

Revista Enfermagem UERJ, 2015
Este estudo objetivou discutir o nível de estresse oriundo do trabalho dos profissionais de enfermagem de três unidadesde um hospital universitário no Rio de Janeiro.
Celia Caldeira Fonseca Kestenberg, Ingryd Cunha Ventura Felipe, Felipe de Oliveira Rossone, Lívia Moreira Delphim, Michele Costa Teotonio   +4 more
doaj   +1 more source