Results 71 to 80 of about 1,587,448 (268)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Alterações no metabolismo da cana-de-açúcar em função da aplicação de maturadores Response of sugarcane metabolism to ripener application

Planta Daninha, 2012
O objetivo deste trabalho foi avaliar as alterações nos níveis de ácido chiquímico e ácido salicílico em plantas de cana-de-açúcar submetidas à aplicação de maturadores.
D.K. Meschede, E.D. Velini, F.G. Tonin, C.A Carbonari   +3 more
doaj   +1 more source

Thiocyanate, a plausible physiological electron donor of gastric peroxidase [PDF]

, 1995
Dipak K. Das, P.K. De, R. K. Banerjee
openalex   +1 more source

Analysis of physiological and proteomic changes in marigold (Calendula officinalis) in response to short term cold stress

, 2023
Nelofer Jan, Umer Majeed, Mubashir Ahmad Wani, Zubair Ahmad Wani, Niranjan Chakraborty, Riffat John   +5 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Effects of Cold Stress on the Hemolymph of the Pacific White Shrimp Penaeus vannamei

Fishes
Temperature is an important factor in the physiological processes of aquatic organisms and can seriously affect several chemical and biological processes in their bodies, including respiratory metabolism, antioxidant capacity, immune capacity, and signal
Jianqiang Zhu, Wenjun Shi, Ran Zhao, Chen Gu, Hui Li, Libao Wang, Xihe Wan   +6 more
doaj   +1 more source

Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota

Frontiers in Microbiology, 2018
Stress, a ubiquitous part of daily human life, has varied biological effects which are increasingly recognized as including modulation of commensal microorganisms residing in the gastrointestinal tract, the gut microbiota.
J. Philip Karl, Adrienne M. Hatch, Steven M. Arcidiacono, Sarah C. Pearce, Ida G. Pantoja-Feliciano, Laurel A. Doherty, Jason W. Soares   +6 more
doaj   +1 more source

Physiological responses of coffee (Coffea arabica L.) plants to biochar application under water deficit conditions

, 2023
Daniel Felipe Reyes-Herrera, Alefsi David Sánchez-Reinoso, Leonardo Lombardini, Hermann Restrepo-Díaz   +3 more
openalex   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source