Results 101 to 110 of about 884,628 (273)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

On the generation mechanism of Pi 2 pulsations in the magnetosphere

Geophysical Research Letters, 1998
We present a theoretical study on how Pi 2 pulsations are excited in the magnetosphere. When impulsive disturbances associated with the substorm onset are assumed at the tailward region, their propagation toward the sunward direction is investigated with a wave equation.
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Study of the $$B^{+}\rightarrow \pi ^{+}\left( \pi ^{+}\pi ^{-}\right) $$ B + → π + π + π - decay in PQCD approach

European Physical Journal C: Particles and Fields
Based on the fitting results of the LHCb collaboration on the contributions of various intermediate resonances to the $$B^{+}\rightarrow \pi ^{+}\pi ^{+}\pi ^{-}$$ B + → π + π + π - decay, we calculate the branching fractions and localized CP asymmetries
Qin Chang, Lei Yang, Zhi-Tian Zou, Ying Li   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Electrochemical Corrosion Behavior Research of Ferritic/Martensitic Stainless Steel

Yuanzineng kexue jishu
Ferritic/martensitic stainless steel has a wide range of applications in reactor engineering. During the service phase, reactor materials are required to have good resistance to high temperatures, radiation, and creep.
WEI Ke1, 2, PI Lixin1, , WANG Hui1, LIU Chao1, ZHANG Peng1
doaj   +1 more source

Right triangular dihedral f-tilings of the sphere: (a, b, pi/2) and (c, c, pi/2)

, 2015
The classification of all dihedral f-tilings of the Riemannian sphere S2, whose prototiles are two right triangles with at least one isosceles, is given. The combinatorial structure and the symmetry group of each tiling is also achieved.
Avelino, Catarina Pina, Santos, Altino
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source