Results 131 to 140 of about 25,442,440 (283)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Midiendo Pi

, 2014
Educação Infantil::Natureza e sociedadeGuia de experimento que permite demonstrar como encontrar e calcular o valor de PI de objetos ...
Varela, Antonio
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Set point tracking of WOA-PIDD²-PI-ISE and GWO-TID-F-ISE controller vs. GA-PI-PD, SIMC-PID and H-infinity controller.

Set point tracking of WOA-PIDD2-PI-ISE and GWO-TID-F-ISE controller vs. GA-PI-PD, SIMC-PID and H-infinity controller.
Amil Daraz (9667034), Farhan Zafar (9667046), Irfan Ahmed Khan (11321310), Suheel Abdullah Malik (9667037), Tayyab Ali (17935896), Farkhunda Bhatti (17965635), Abdul Rahman Afzal (17965632)   +6 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

P1260: UNRAVELING THE GENETICS OF TRANSFORMED SPLENIC MARGINAL ZONE LYMPHOMA

HemaSphere, 2022
M. Grau, C. López, A. Navarro, G. Clot, F. Nadeu, G. Bastidas, M. Alcoceba, M. J. Baptista, M. Blanes, F. Climent, D. Colomer, D. Costa, E. Domingo-Domènech, P. Forcada, A. Enjuanes, L. Escoda, G. Frigola, E. Giné, M. Lopez-Guerra, A. Rivas-Delgado, L. Vicente-Folch, A. Wotherspoon, E. Campo, A. López-Guillermo, E. Matutes, S. Beà   +25 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Alpha-2 (1320) and Pi-2 (1670) Formation In the Reaction Gamma-gamma-]pi+pi-pi-0

, 1990
Alpha-2 (1320) and Pi-2 (1670) Formation In the Reaction Gamma-gamma-]pi+pi-pi-
U. HADINGER, L. POGGIOLI, M. DAVIER, H. OBERLACK, F. FERRAROTTO, J. GRUNHAUS, K. H. RANITZSCH, H. KROHA, J. AHME, P. SCHACHT, G. ALEXANDER, C. KIESLING, H. JUNG, R. KOTTHAUS, R. GEORGE, V. BLOBEL, D. C. FRIES, G. COZZIKA, C. MILSTENE, G. BUSCHHORN, R. SEUFERT, G. BELLA, L. CRIEGEE, J. H. KOHNE, G. FLUGGE, W. DEBOER, H. J. BEHREND, W. WIEDENEMANN, M. RIVOAL, O. HAMON, F. KAPUSTA, J. H. FIELD, O. PODOBRIN, M. GOLDBERG, G. FRANKE, D. W. KIM, J. HANSMEYER, H. FENNER, F. LEDIBERDER, G. G. WINTER, J. HARJES, J. ENGLER, D. LUERS, D. HENDRY, J. HAISSINSKI, S. SCHOLZ, A. BECK, W. D. APEL, J. FUSTER, A. J. CAMPBELL, G. SHOOSHTARI, W. BREHM, H. SCHNEIDER, K. BLOHM, J. MEYER, M. HAHN, A. KLATCHKO, G. DAGOSTINI, V. JOURNE, P. J. BUSSEY, S. LUMSDON, J. J. VEILLET, I. O. SKILLICORN, H. SPITZER, K. GAMERDINGER, J. F. GRIVAZ, M. FEIND, Y. DUCROS, J. H. PETERS, G. GRINDHAMMER, B. STELLA, A. LEVY, IACOVACCI, MICHELE, P. GABRIEL, V. SCHRODER, P. GROSSEWIESMANN, B. GUNDERSON, H. MULLER, H. KUSTER   +78 more
core