Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
A novel SLC20A2 nonsense variant and mechanistic studies of primary brain calcification. [PDF]
Li Y +7 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Flatback Deformity and Stiff Pelvic Mobility Alter the Optimal Cup Anteversion After Total Hip Arthroplasty: Insights from 3D-to-2D Model-Image Registration Analysis. [PDF]
Konishi T +13 more
europepmc +1 more source
Benchmarking Raspberry Pi 2 Beowulf Cluster
Ioannis Kostouros +2 more
openaire +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Erratum: Global parameterization of $$\pi \pi $$ π π scattering up to 2 GeV
J. R. Pelaez +2 more
doaj +1 more source
Development and Internal Validation of a Gradient Boosting Model for Pressure Injury Risk in the ICU. [PDF]
Qian S +9 more
europepmc +1 more source
Object tracking has become a large field with a wide range of algorithms being used as a result. This thesis focuses on analyzing the performance in terms of successful tracking on moving objects using two popular tracking systems, Kanade-Lucas-Tomasi Feature Tracker and Camshift, on a single-board computer with live camera feed.
openaire +1 more source
Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source

