Results 161 to 170 of about 689,548 (248)

Polygenic risk scores for premagnetic resonance imaging risk stratification in men with clinically suspected prostate cancer. [PDF]

J Natl Cancer Inst
Fischer MP, Mayer A, Braun A, Kraft J, Hansen CM, Baumgärtner GL, Asbach P, Padhani AR, Penzkofer T, König F, Awasthi S, Makowski MR, Ripke S, Hamm CA.   +13 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

¹H NMR-based metabolomics reveals metabolic changes in porcine ingesta and serum during Ascaris suum infection. [PDF]

Parasit Vectors
Wagner L, Springer A, Koehler S, Brüggemann DA, Strube C.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Purified zymogens reveal mechanisms of snake venom metalloproteinase auto-activation. [PDF]

Elife
Hall S, Cardoso IA, Wilkinson MC, Carretero MM, Lingappa S, Rand B, Shen D, Boldrini-França J, Stenner R, Menzies SK, Balchin G, Hus KK, Vincentelli R, Mumford A, Poole A, Casewell NR, Berger I, Schaffitzel C.   +17 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Synthesis and <i>in silico</i> insights of some tetrahydrobenzothienopyrimidine candidates as multi-target antimicrobial, antiproliferative, and antiviral agents. [PDF]

RSC Adv
Elgubbi AS, Hamed S, Alanazi BN, Ahmed HA, Ramadan SK.   +4 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Clinical evaluation of the peripheral perfusion index as a predictor of femoral nerve block efficacy in unilateral arthroscopic meniscal surgery. [PDF]

Front Neurol
Gong Y, He Q, Zhang L, Wei W, Zhang CMJ.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source