Results 181 to 190 of about 3,793,930 (259)

Feasibility of Concurrent 1 H MRS and 31 P MRSI at 7 T: Brain Energy Metabolism Responses to Hyperglycemia. [PDF]

NMR Biomed
Widmaier M, Matson BC, Emir U, Hwang JJ.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Enhancing the Prospective Acceptability of a Paediatric Speech and Language Therapy Intervention With Parents From Under-Represented Communities. [PDF]

Health Expect
Rodgers L, Botting N, Herman R.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases. [PDF]

EBioMedicine
Konuri A, Leal GC, Zebarjadi N, Habich A, Castellanos-Perilla N, Gonzalez MC, Taylor JP, Firbank M, Alcolea D, Bejanin A, Segers K, Benoit F, Isik AT, Samanci B, Cháfer-Pericás C, Wade-Martins R, Hu MTM, Bhome R, Dobreva I, Walker Z, Aarsland D, Westman E, Ferreira D, Halliday G, Lewis SJG, Weil RS, Landin-Romero R, Lambert C, Oxtoby NP, Matar E.   +29 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Spatial membrane lipid remodelling encodes epithelial lineage and state in human colon cancer. [PDF]

EBioMedicine
Rodriguez RM, Pérez-Romero K, Maimó-Barceló A, Ximelis T, Huergo-Baños C, Martínez MA, Segura-Sampedro JJ, Morales-Soriano R, Pineño-Flores C, García-Granero Á, Jerí S, Aransay AM, Fernández JA, Barceló-Coblijn G.   +13 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Vascular dynamics in diabetic retinopathy: A systematic review and meta-analysis of ophthalmic Doppler indices in diabetic and non-diabetic populations. [PDF]

Diab Vasc Dis Res
Hanafi M, Ardyanto TD, Soewondo W, Pamungkasari EP, Muthmainah, Putranto W, Indrakila S.   +6 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source