Results 121 to 130 of about 728,464 (246)
Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceStudy of B0 -> D*- pi+ pi- pi+ and B0 -> D*- K+ pi- pi+ decays
, 2013 Comment: 12 pages, 2 ...LHCb collaboration, Aaij, R., Beteta, C. Abellan, Adametz, A., Adeva, B., Adinolfi, M., Adrover, C., Affolder, A., Ajaltouni, Z., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Cartelle, P. Alvarez, Alves Jr, A. A., Amato, S., Amhis, Y., Anderlini, L., Anderson, J., Andreassen, R., Appleby, R. B., Gutierrez, O. Aquines, Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Bachmann, S., Back, J. J., Baesso, C., Balagura, V., Baldini, W., Barlow, R. J., Barschel, C., Barsuk, S., Barter, W., Bauer, Th., Bay, A., Beddow, J., Bediaga, I., Belogurov, S., Belous, K., Belyaev, I., Ben-Haim, E., Benayoun, M., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bettler, M. -O., van Beuzekom, M., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Bjørnstad, P. M., Blake, T., Blanc, F., Blanks, C., Blouw, J., Blusk, S., Bobrov, A., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borgia, A., Bowcock, T. J. V., Bowen, E., Bozzi, C., Brambach, T., Brand, J. van den, Bressieux, J., Brett, D., Britsch, M., Britton, T., Brook, N. H., Brown, H., Burducea, I., Bursche, A., Buytaert, J., Cadeddu, S., Callot, O., Calvi, M., Gomez, M. Calvo, Camboni, A., Campana, P., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carranza-Mejia, H., Carson, L., Akiba, K. Carvalho, Casse, G., Cattaneo, M., Cauet, Ch., Charles, M., Charpentier, Ph., Chen, P., Chiapolini, N., Chrzaszcz, M., Ciba, K., Vidal, X. Cid, Ciezarek, G., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coca, C., Coco, V., Cogan, J., Cogneras, E., Collins, P., Comerma-Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Couturier, B., Cowan, G. A., Craik, D., Cunliffe, S., Currie, R., D'Ambrosio, C., David, P., David, P. N. Y., De Bonis, I., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Silva, W., De Simone, P., Decamp, D., Deckenhoff, M., Degaudenzi, H., Del Buono, L., Deplano, C., Derkach, D., Deschamps, O., Dettori, F., Di Canto, A., Dickens, J., Dijkstra, H., Dogaru, M., Bonal, F. Domingo, Donleavy, S., Dordei, F., Suárez, A. Dosil, Dossett, D., Dovbnya, A., Dupertuis, F., Dzhelyadin, R., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., van Eijk, D., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Rifai, I. El, Elsasser, Ch., Elsby, D., Falabella, A., Färber, C., Fardell, G., Farinelli, C., Farry, S., Fave, V., Ferguson, D., Albor, V. Fernandez, Rodrigues, F. Ferreira, Ferro-Luzzi, M., Filippov, S., Fitzpatrick, C., Fontana, M., Fontanelli, F., Forty, R., Francisco, O., Frank, M., Frei, C., Frosini, M., Furcas, S., Furfaro, E., Torreira, A. Gallas, Galli, D., Gandelman, M., Gandini, P., Gao, Y., Garofoli, J., Gersabeck, E., Gligorov, V. V., Graugés, E., He, J., Hoballah, M., Koppenburg, P., Lafferty, G., Latham, T., Gac, R. Le, Lefèvre, R., Leroy, O., Martens, A., Martinelli, M., Santos, D. Martinez, Massafferri, A., Nasteva, I., Needham, M., Niess, V., Orlandea, M., Parkinson, C. J., Perazzini, S., Perrin-Terrin, M., Petrolini, A., Phan, A., Casasus, M. Plo, Poluektov, A., Potterat, C., Navarro, A. Puig, Rangel, M. S., Raven, G., Rodrigues, E., Sarti, A., Schiller, M., Schmelling, M., Schneider, O., Sciascia, B., Serra, N., Serrano, J., Seyfert, P., Shears, T., Souza, D., Steinkamp, O., Stone, S., van Tilburg, J., Tisserand, V., Tonelli, D., Gomez, R. Vazquez, Regueiro, P. Vazquez, Watson, N. K., Yang, Z., Zhang, Y. +250 moreopenaire +4 more sourcesHeterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceCell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceAmplitude Analysis of the Decays eta ' -> pi(+)pi(-)pi(0) and eta' -> pi(0)pi(0)pi(0)
, 2017 Based on a sample of 1.31 x 10(9) J/Psi events collected with the BESIII detector, an amplitude analysis of the isospin-violating decays eta' -> pi(+)pi(-)pi(0) and eta' -> pi(0)pi(0)pi(0) is performed. A significant P-wave contribution from eta' -> rho(+/-)eta(-/+) is observed for the first time in eta' -> pi(+)pi(-)pi(0).Ablikim, M., Achasov, M. N., Ai, X. C., Albayrak, O., Albrecht, M., Ambrose, D. J., Amoroso, A., An, F. F., An, Q., Bai, J. Z., Baldini Ferroli, R., Ban, Y., Bennett, D. W., Bennett, J. V., Bertani, M., Bettoni, D., Bian, J. M., Bianchi, F., Boger, E., Boyko, I., Briere, R. A., Cai, H., Cai, X., Cakir, O., Calcaterra, A., Cao, G. F., Cetin, S. A., Chang, J. F., Chelkov, G., Chen, G., Chen, H. S., Chen, H. Y., Chen, J. C., Chen, M. L., Chen, S., Chen, S. J., Chen, X., Chen, X. R., Chen, Y. B., Cheng, H. P., Chu, X. K., Cibinetto, G., Dai, H. L., Dai, J. P., Dbeyssi, A., Dedovich, D., Deng, Z. Y., Denig, A., Denysenko, I., Destefanis, M., De Mori, F., Ding, Y., Dong, C., Dong, J., Dong, L. Y., Dong, M. Y., Dou, Z. L., Du, S. X., Duan, P. F., Fan, J. Z., Fang, J., Fang, S. S., Fang, X., Fang, Y., FARINELLI, Riccardo, Fava, L., Fedorov, O., Feldbauer, F., Felici, G., Feng, C. Q., Fioravanti, E., Fritsch, M., Fu, C. D., Gao, Q., Gao, X. L., Gao, X. Y., Gao, Y., Gao, Z., GARZIA, Isabella, Goetzen, K., Gong, L., Gong, W. X., Gradl, W., Greco, M., Gu, M. H., Gu, Y. T., Guan, Y. H., Guo, A. Q., Guo, L. B., Guo, R. P., Guo, Y., Guo, Y. P., Haddadi, Z., Hafner, A., Han, S., Hao, X. Q., Harris, F. A., He, K. L., Held, T., Heng, Y. K., Hou, Z. L., Hu, C., Hu, H. M., Hu, J. F., Hu, T., Hu, Y., Huang, G. S., Huang, J. S., Huang, X. T., Huang, X. Z., Huang, Y., Huang, Z. L., Hussain, T., Ji, Q., Ji, Q. P., Ji, X. B., Ji, X. L., Jiang, L. W., Jiang, X. S., Jiang, X. Y., Jiao, J. B., Jiao, Z., Jin, D. P., Jin, S., Johansson, T., Julin, A., Kalantar Nayestanaki, N., Kang, X. L., Kang, X. S., Kavatsyuk, M., Ke, B. C., Kiese, P., Kliemt, R., Kloss, B., Kolcu, O. B., Kopf, B., Kornicer, M., Kupsc, A., Kühn, W., Lange, J. S., Lara, M., Larin, P., Leng, C., Li, C., Li, Cheng, Li, D. M., Li, F., Li, F. Y., Li, G., Li, H. B., Li, H. J., Li, J. C., Li, Jin, Li, K., Li, K., Li, Lei, Li, P. R., Li, Q. Y., Li, T., Li, W. D., Li, W. G., Li, X. L., Li, X. N., Li, X. Q., Li, Y. B., Li, Z. B., Liang, H., Liang, Y. F., Liang, Y. T., Liao, G. R., Lin, D. X., Liu, B., Liu, B. J., Liu, C. X., Liu, D., Liu, F. H., Liu, Fang, Liu, Feng, Liu, H. B., Liu, H. H., Liu, H. H., Liu, H. M., Liu, J., Liu, J. B., Liu, J. P., Liu, J. Y., Liu, K., Liu, K. Y., Liu, L. D., Liu, P. L., Liu, Q., Liu, S. B., Liu, X., Liu, Y. B., Liu, Z. A., Liu, Zhiqing, Loehner, H., Lou, X. C., Lu, H. J., Lu, J. G. +199 moreopenaire +2 more sourcesHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceStudy of reaction pi- A --> pi+pi-pi- A at VES setup
, 2001 Comment: 5 pages, 4 figures, LaTeX2e, aipproc class, to be published in the proceedings of the IX international Conference on Hadron Spectroscopy, HADRON2001, 25 august - 1 september, Protvino ...Kachaev, Igor, Collaboration, for VESopenaire +1 more sourceProteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi +10 morewiley +1 more source
