Results 111 to 120 of about 728,464 (246)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

$\pi \to \pi\pi$ results in nuclei

, 2001
The Crystal Ball ($CB$) collaboration at $BNL$ has recently presented results regarding a study of the $\pi^- A \to \pi^0\pi^0 A^\prime$ reaction on $H, D, C, Al$ and $Cu$, using a nearly 4$\pi$ detector. Similar results, but for the $\pi^+ A \to \pi^+\pi^{\pm} A^\prime$ reaction on $^{2}H$, $^{12}C$, $^{40}Ca$, and $^{208}Pb$, have been published ...
Camerini, P., Fragiacomo, E., Grion, N., Rui, R., Brack, J. T., Gibson, E. F., Hofman, G. J., Mathie, E. L., Meier, R., Raywood, K., Sevior, M. E., Smith, G. R., Tacik, R.   +12 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Analysis of $\pi^- \pi^+$ Scattering in $\pi^+$p $\to$ $\pi^- \pi^+ \pi^+p$ Interactions [PDF]

, 1969
E. Malamud, P. Schlein, T. Trippe, D. Brown, G. Gidal   +4 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dalitz Plot Analyses of B^- \to D^+ \pi^-\pi^-, B^+ \to \pi^+ \pi^- \pi^+ and D^+_s \to \pi^+ \pi^- \pi^+ at BABAR

, 2009
Comment: 6 pages, 7 figures, To be published in the proceedings of DPF-2009, Detroit, MI, July 2009, eConf ...
openaire   +1 more source

The $e^+ e^-\to 2(\pi^+\pi^-)\pi^0$, 2(\pi^+\pi^-)\eta$, $K^+ K^-\pi^+\pi^-\pi^0$ and $K^+ K^-\pi^+\pi^-\eta$ Cross Sections Measured with Initial-State Radiation

, 2007
Comment: 30 pages, 43 postscript figures, submitted to Phys.Rev ...
AUBERT B, BONA M, BOUTIGNY D, KARYOTAKIS Y, LEES JP, POIREAU V, PRUDENT X, TISSERAND V, ZGHICHE A, TICO JG, GRAUGES E, LOPEZ L, PALANO A, PAPPAGALLO M, EIGEN G, STUGU B, SUN L, ABRAMS GS, BATTAGLIA M, BROWN DN, BUTTON SHAFER J, CAHN RN, GROYSMAN Y, JACOBSEN RG, KADYK JA, KERTH LT, KOLOMENSKY YG, KUKARTSEV G, PEGNA DL, LYNCH G, MIR LM, ORIMOTO TJ, OSIPENKOV IL, RONAN MT, TACKMANN K, TANABE T, WENZEL WA, SANCHEZ PD, HAWKES CM, WATSON AT, KOCH H, SCHROEDER T, WALKER D, ASGEIRSSON DJ, CUHADAR DONSZELMANN T, FULSOM BG, HEARTY C, MATTISON TS, MCKENNA JA, BARRETT M, KHAN A, SALEEM M, TEODORESCU L, BLINOV VE, BUKIN AD, DRUZHININ VP, GOLUBEV VB, ONUCHIN AP, SEREDNYAKOV SI, SKOVPEN YI, SOLODOV EP, TODYSHEV KY, BONDIOLI M, CURRY S, ESCHRICH I, KIRKBY D, LANKFORD AJ, LUND P, MANDELKERN M, MARTIN EC, STOKER DP, ABACHI S, BUCHANAN C, FOULKES SD, GARY JW, LIU F, LONG O, SHEN BC, VITUG GM, ZHANG L, PAAR HP, RAHATLOU, SHAHRAM, SHARMA V, BERRYHILL JW, CAMPAGNARI C, CUNHA A, DAHMES B, HONG TM, KOVALSKYI D, RICHMAN JD, BECK TW, EISNER AM, FLACCO CJ, HEUSCH CA, KROSEBERG J, LOCKMAN WS, SCHALK T, SCHUMM BA, SEIDEN A, WILSON MG, WINSTROM LO, CHEN E, CHENG CH, FANG F, HITLIN DG, NARSKY I, PIATENKO T, PORTER FC, ANDREASSEN R, MANCINELLI G, MEADOWS BT, MISHRA K, SOKOLOFF MD, BLANC F, BLOOM PC, CHEN S, FORD WT, HIRSCHAUER JF, KREISEL A, NAGEL M, NAUENBERG U, OLIVAS A, SMITH JG, ULMER KA, WAGNER SR, ZHANG J, GABAREEN AM, SOFFER A, TOKI WH, WILSON RJ, WINKLMEIER F, ALTENBURG DD, FELTRESI E, HAUKE A, JASPER H, MERKEL J, PETZOLD A, SPAAN B, WACKER K, KLOSE V, KOBEL MJ, LACKER HM, MADER WF, NOGOWSKI R, SCHUBERT J, SCHUBERT KR, SCHWIERZ R, SUNDERMANN JE, VOLK A, BERNARD D, BONNEAUD GR, LATOUR E, LOMBARDO V, THIEBAUX C, VERDERI M, CLARK PJ, GRADL W, MUHEIM F, PLAYFER S, ROBERTSON AI, WATSON JE, XIE Y, ANDREOTTI M, BETTONI D, BOZZI C, CALABRESE R, CECCHI A, CIBINETTO G, FRANCHINI P, LUPPI E, NEGRINI M, PETRELLA A, PIEMONTESE L, PRENCIPE E, SANTORO V, ANULLI F, BALDINI FERROLI R, CALCATERRA A, DE SANGRO R, FINOCCHIARO G, PACETTI S, PATTERI P, PERUZZI IM, PICCOLO M, RAMA M, ZALLO A, BUZZO A, CONTRI R, LO VETERE M, MACRI MM, MONGE MR, PASSAGGIO S, PATRIGNANI C, ROBUTTI E, SANTRONI A, TOSI S, CHAISANGUANTHUM KS, MORII M, WU J, DUBITZKY RS, DONG L, ARNAUD N, SERRANO J, SORDINI V, DI LODOVICO F, SALVATORE F, CHEN C, DALLAPICCOLA C, SCIACCA C, RAVEN G, STROM D, STRUBE J, CALDERINI G, DEL BUONO L, OCARIZ J, CARPINELLI M, MARCHIORI G, BELLINI, Fabio, CAVOTO, Gianluca, DEL RE, Daniele, FACCINI, Riccardo, FERRONI, Fernando, VOENA C, EBERT M, ADYE T, ESCALIER M, VASSEUR G, KAMINSKI J, SU D, BOMBEN M, LANCERI L, ALBERT J, BANERJEE S, KOWALEWSKI R, DASU S   +234 more
openaire   +5 more sources