Results 91 to 100 of about 728,464 (246)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Search for the photo-excitation of exotic mesons in the pi+pi+pi- system

Physical review letters, 2008
6 pages, 5 figures, to be submitted to Phys.Rev ...
Nozar, M., Salgado, C., Weygand, D.P., Guo, L., Adams, G., Li, J., Eugenio, P., Amaryan, M.J., Anghinolfi, M., Asryan, G., Avakian, H., Bagdasaryan, H., Baillie, N., Ball, J.P., Baltzell, N.A., Barrow, S., Battaglieri, M., Bedlinskiy, I., Bektasoglu, M., Bellis, M., Benmouna, N., Berman, B.L., Biselli, A.S., Blaszczyk, L., Bonner, B.E., Bouchigny, S., Boiarinov, S., Bradford, R., Branford, D., Briscoe, W.J., Brooks, W.K., Bültmann, S., Burkert, V.D., Butuceanu, C., Calarco, J.R., Careccia, S.L., Carman, D.S., Carnahan, B., Casey, L., Cazes, A., Chen, S., Cheng, L., Cole, P.L., Collins, P., Coltharp, P., Cords, D., Corvisiero, P., Crabb, D., Crannell, H., Crede, V., Cummings, J.P., Dale, D., Dashyan, N., de Masi, R., de Vita, R., de Sanctis, E., Degtyarenko, P.V., Denizli, H., Dennis, L., Deur, A., Dharmawardane, K.V., Dhuga, K.S., Dickson, R., Djalali, C., Dodge, G.E., Doughty, D., Dugger, M., Dytman, S., Dzyubak, O.P., Egiyan, H., Egiyan, K.S., El Fassi, L., Elouadrhiri, L., Fatemi, R., Fedotov, G., Feuerbach, R.J., Forest, T.A., Fradi, A., Funsten, H., Garçon, M., Gavalian, G., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Gothe, R.W., Griffioen, K.A., Guidal, M., Guillo, M., Guler, N., Gyurjyan, V., Hadjidakis, C., Hafidi, K., Hakobyan, H., Hanretty, C., Hardie, J., Hassall, N., Heddle, D., Hersman, F.W., Hicks, K., Hleiqawi, I., Holtrop, M., Hyde-Wright, C.E., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Ito, M.M., Jenkins, D., Jo, H.S., Johnstone, J.R., Joo, K., Juengst, H.G., Kalantarians, N., Kellie, J.D., Khandaker, M., Kim, W., Klein, A., Klein, F.J., Kossov, M., Krahn, Z., Kramer, L.H., Kubarovsky, V., Kuhn, J., Kuhn, S.E., Kuleshov, S.V., Kuznetsov, V., Lachniet, J., Laget, J.M., Langheinrich, J., Lawrence, D., Livingston, K., Lu, H.Y., Maccormick, M., Markov, N., Mattione, P., Mcaleer, S., Mckinnon, B., Mcnabb, J.W.C., Mecking, B.A., Mehrabyan, S., Mestayer, M.D., Meyer, C.A., Mibe, T., Mikhailov, K., Mirazita, M., Miskimen, R., Mokeev, V., Moreno, B., Moriya, K., Morrow, S.A., Moteabbed, M., Mueller, J., Munevar, E., Mutchler, G.S., Nadel-Turonski, P., Nasseripour, R., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B.B., Niroula, M.R., Niyazov, R.A., O'Rielly, G.V., Osipenko, M., Ostrovidov, A.I., Park, K., Pasyuk, E., Paterson, C., Anefalos Pereira, S., Philips, S.A., Pierce, J., Pivnyuk, N., Pocanic, D., Pogorelko, O., Polli, E., Popa, I., Pozdniakov, S., Preedom, B.M., Price, J.W., Prok, Y., Protopopescu, D., Qin, L.M., Raue, B.A., Riccardi, G., Ricco, G., Ripani, M., Ritchie, B.G., Ronchetti, F., Rosner, G., Rossi, P., Rubin, P.D., Sabatié, F., Salamanca, J., Santoro, J.P., Sapunenko, V., Schumacher, R.A., Serov, V.S., Sharabian, Y.G., Smith, E.S., Thoma, U., Zana, L.   +202 more
openaire   +6 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Sensory remapping: a possible therapy option

Medicina, 2023
The human sensory receptors are morphologically specialized to transduce specific stimuli into the brain. However, when an injury occurs, mainly in the spinal cord, which can be of traumatic or non-traumatic origin, it provokes various degrees of ...
Wanderson Silva Macedo de Sousa, Matheus Sam do Santos Lemos, Diego Agripino Chagas Silva, Therezza Inácia Martins Gomes Leite, Ana Claúdia de Miranda Adad, Ana Flávia Ferreira Sousa, Gabriela Veiga Macedo e Araújo, Jonatas Paulino da Cunha Monteiro Ribeiro   +7 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source