Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The phase of the $\sigma \to \pi \pi$ amplitude in $J/\Psi \to \omega \pi^ + \pi^-$ [PDF]
The phase variation of the sigma -> pi-pi amplitude is accurately determined as a function of mass from BES II data for J/Psi -> omega-pi-pi. The determination arises from interference with the strong b1(1235)-pi amplitude. The observed phase variation agrees within errors with that in pi-pi elastic scattering.
openaire +2 more sources
Measurements of the Branching fractions for $B_(s) -> D_(s)\pi\pi\pi$ and $\Lambda_b^0 -> \Lambda_c^+\pi\pi\pi$ [PDF]
Branching fractions of the decays $H_b\to H_c\pi^-\pi^+\pi^-$ relative to $H_b\to H_c\pi^-$ are presented, where $H_b$ ($H_c$) represents B^0-bar($D^+$), $B^-$ ($D^0$), B_s^0-bar ($D_s^+$) and $\Lambda_b^0$ ($\Lambda_c^+$). The measurements are performed with the LHCb detector using 35${\rm pb^{-1}}$ of data collected at $\sqrt{s}=7$ TeV. The ratios of
LHCb Collaboration +246 more
openaire +6 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
With the increasing demand for renewable energy, solar power has emerged as a promising option for sustainable power generation. However, the effectiveness and efficiency of solar power systems rely on the ability to effectively manage their performance,
Hole Shreyas Rajendra, Das Goswami Agam
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Finite-volume spectrum of $\pi^+\pi^+$ and $\pi^+\pi^+\pi^+$ systems
The ab-initio understanding of hadronic three-body systems above threshold, such as exotic resonances or the baryon spectrum, requires the mapping of the finite-volume eigenvalue spectrum, produced in lattice QCD calculations, to the infinite volume. We present the first application of such a formalism to a physical system in form of three interacting ...
Mai, Maxim, Doring, Michael
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Assessment of Hydrochemical Characteristics of Groundwater Resources of the aquifer of the Sari-Ghaemshahr plain for Drinking and Irrigation Purposes [PDF]
The Sari-Ghaemshahr plain is located in the province of Mazandaran, in the southeast boarders of the Caspian Sea. The water of 44 production wells was sampled in the fall of 2011 and the spring of 2012 to determine their suitability for drinking and ...
H. Moghimi
doaj

