Results 101 to 110 of about 231,101 (299)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Values of multiparametric and biparametric MRI in diagnosing clinically significant prostate cancer: a multivariate analysis

BMC Urology
Background To investigate the value of semi-quantitative and quantitative parameters (PI-RADS score, T2WI score, ADC, Ktrans, and Kep) based on multiparametric MRI (mpMRI) or biparametric MRI (bpMRI) combined with prostate specific antigen density (PSAD)
Xiao Feng, Xin Chen, Peng Peng, He Zhou, Yi Hong, Chunxia Zhu, Libing Lu, Siyu Xie, Sijun Zhang, Liling Long   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Scatter plot showing the correlation between mean middle cerebral artery pulsatility index (PI) and resistivity index (RI), and pollutant standards index (PSI).

, 2019
Scatter plot showing the correlation between mean middle cerebral artery pulsatility index (PI) and resistivity index (RI), and pollutant standards index (PSI).
Bridget S. Ng (6180464), Hock-Luen Teoh (5495150), Vijay K. Sharma (505550), Leonard L. Yeo (6180470), Jintao Chen (2559184), Zhengdao Du (6180482), Roger C. Ho (3937307), Lily Y. Wong (6180485), Amit Batra (6180488), Benjamin Y. Tan (6180452), Nicholas J. Ngiam (6180461), Nabin Sarkar (6180491), Young H. Chee (6180479), Aloysius S. Leow (6180458), Manasi Sharma (6180467), Adriel Z. Leong (6180455), Chiew S. Hong (6180476), Philip A. Seow (6180473)   +17 more
core   +1 more source

Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study

Brain Research Bulletin
Background: Primary insomnia (PI) is increasingly recognized as a brain network disorder associated with cognitive impairment. Emerging evidence suggests that glymphatic system dysfunction may underlie these deficits by impairing brain clearance ...
Chen Wang, Tian Zhang, Huizhen Lu, Ziliang Xu, Shengnan Wei, Chaozong Ma, Peng Fang, Yuanqiang Zhu, Fan Guo   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bound for vertex PI index in terms of simple graph parameters

, 2013
The vertex PI index is a distance-based molecular structure descriptor, that recently found numerous chemical applications. In this letter we obtain a lower bound on the vertex PI index of a connected graph in terms of number of vertices, edges, pendent ...
das, kinkar, Gutman, Ivan
core   +1 more source

Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15 [PDF]

, 2010
Background: Little is known about whether associations between childhood adiposity and later adverse cardiovascular health outcomes are driven by tracking of overweight from childhood to adulthood and/or by vascular and metabolic changes from childhood ...
Kate Tilling, Smith George Davey, Benfield, LL, Lawlor Debbie A., Sattar, N, Sattar, N., Smith, GD, Ness, AR, Andy R. Ness, Tilling, K., Sattar Naveed, Laura D Howe, Benfield Li, Davey Smith, G, Debbie A. Lawlor, Tilling Kate, Logue Jennifer, Jennifer Logue, Howe Laura D., Howe, L.D., Andy R Ness, Lawlor, D, Li Benfield, Logue, J., Logue, J, Benfield, L., Ness Andy R., Naveed Sattar, Lawlor, DA, Debbie A Lawlor, Laura D. Howe, Hernandez, A.V., George Davey Smith, Davey Smith, G., Howe, LD, Ness, A.R., Benfield, L, Lawlor, D.A., Tilling, K, Ness, A   +39 more
core   +1 more source

Association Between DMFT Index, Dental Plaque, and Pre‐eclampsia in Pregnant Women: A Case–Control Study

Clinical and Experimental Dental Research
Objectives This study investigates the association between Decayed, Missing, and Filled Teeth (DMFT) Index, dental plaque (assessed via Plaque Index [PI]), and pre‐eclampsia in pregnant women.
Mehdi Shirinzad, Mohammad Moradi Dalir, Azita Tiznobaik, Farideh Kazemi, Zohreh Momenimovahed   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source