Results 31 to 40 of about 698,086 (300)

PICO-LON Project for WIMPs search

, 2007
Highly segmented inorganic crystal has been shown to have good performance for dark matter search. The energy resolution of ultra thin and large area NaI(Tl) scintillator has been developed. The estimated sensitivity for spin-dependent excitation of 127I
Ejiri, Hiroyasu, Fushimi, Ken-Ichi, Hazama, Ryuta, Ichihara, Kayoko, Imagawa, Kyoshiro, Ito, Hiroshi, Kamedai, Yuuki, Koori, Norihiko, Nakamura, Hidehito, Nakayama, Shintaro, Nomachi, Masaharu, Shima, Tatsushi, Umehara, Saori, Yasudai, Kensuke, Yoshida, Sei   +14 more
core   +1 more source

Ciclos de negocios en Colombia, 1975-2011

Lecturas de Economía, 2013
Resumen: Se propone una cronología para los ciclos de negocios de Colombia en la concepción clásica del NBER; esto es, determinando las fechas de picos y valles en la actividad económica sin separar las series utilizadas en sus componentes transitorio y ...
Viviana Algonso, Luis Eduardo Arango, Fernando Arias, Guillermo Cangrejo, Jose David Pulido   +4 more
doaj   +2 more sources

A Holistic Quality Evaluation, Selection and Improvement Approach driven by Multilevel Goals and Strategies

CLEI Electronic Journal, 2016
Organizations should establish business goals and check for their achievement in a systematic and disciplined way. In order to know if a business goal is achieved, it should be necessary to consider information need goals that also can require satisfying
Belen Rivera, Pablo Becker, Fernanda Papa, Luis Olsina   +3 more
doaj   +1 more source

Applying an Improving Strategy that embeds Functional and Non-Functional Requirements Concepts

Journal of Computer Science and Technology, 2019
Organizations should set and reach business goals for varied purposes using the suitable strategies. Basically, a strategy specifies the activities, methods and another related resources that should be considered in order to achieve a given goal purpose.
Pablo Becker, Guido Tebes, Denis Peppino, Luis Olsina   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

REHABILITACION DE SUELOS HORTÍCOLAS: IMPACTO DE PRÁCTICAS AGRÍCOLAS CON USO DE YESO Y DRENAJE

Fave: Sección Ciencias Agrarias, 2017
El exceso de Na + , carbonatos y bicarbonatos presentes en el agua de riego incrementan el pH, la conductividad eléctrica (CE) y el porcentaje de sodio intercambiable (PSI), afectando el crecimiento de los cultivos.
A. MUGUIRO, C. ÁLVAREZ, F. BABINEC, R. MARANO   +3 more
doaj   +1 more source

Promoting Independence Through Effective Interventions For Adults With ALS [PDF]

, 2020
PICO Question What are effective occupational therapy interventions for adults with ALS to improve participation in ADLs/IADLs? Objectives Define amyotrophic lateral sclerosis (ALS) and recognize the prevalence Identify and describe evidence-based ...
Gluchowski, OTS, Renee, Harris, OTS, Hannah, Heineman, OTS, Jaclyn, Kendro, OTS, Kimberly, Malosky, OTS, Heather   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source