Results 41 to 50 of about 207,364 (249)

PICO-based problem solving (question-answer) of the ST-segment elevation in the aVR lead in a patient with chest pain referred to a hospital emergency department: Letter to Editor

مجله دانشگاه علوم پزشکی بیرجند, 2022
In evidence-based medicine, constructing research questions is the most important part of research integration. Formulating a research question is the first step to conducting a credible and valuable research.
Ali MoeziBady, Mohammad Yousof Qoddusi, Nahid Azdaki, Nazanin Hanafi Bojd, Neda Partovi   +4 more
doaj  

Seismic vulnerability of churches in Faial and Pico islands, Azores [PDF]

, 2012
Earthquakes represent one of the main cause of serious damage and loss of historic and architectural heritage. Interventions to preserve these building should start with a careful knowledge and assessment of their seismic vulnerability, in order to ...
Costa, A., Ferreira, T., Lagomarsino, S., Curti, E., Magalhães, J. M., Varum, H., Vicente, R.   +6 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Holistic Quality Evaluation, Selection and Improvement Approach driven by Multilevel Goals and Strategies

CLEI Electronic Journal, 2016
Organizations should establish business goals and check for their achievement in a systematic and disciplined way. In order to know if a business goal is achieved, it should be necessary to consider information need goals that also can require satisfying
Belen Rivera, Pablo Becker, Fernanda Papa, Luis Olsina   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Applying an Improving Strategy that embeds Functional and Non-Functional Requirements Concepts

Journal of Computer Science and Technology, 2019
Organizations should set and reach business goals for varied purposes using the suitable strategies. Basically, a strategy specifies the activities, methods and another related resources that should be considered in order to achieve a given goal purpose.
Pablo Becker, Guido Tebes, Denis Peppino, Luis Olsina   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Digital Transformation of Education in Indonesia: A Conceptual Framework For Evaluation

Jurnal Educative
Advances in information and communication technology have driven significant changes in Indonesia's education ecosystem. Various school digitalization initiatives, including the provision of digital devices, learning platforms, and the development of ...
Riko Pandu Wijaya, Komarudin, Aip Badrujaman   +2 more
doaj   +1 more source

REHABILITACION DE SUELOS HORTÍCOLAS: IMPACTO DE PRÁCTICAS AGRÍCOLAS CON USO DE YESO Y DRENAJE

Fave: Sección Ciencias Agrarias, 2017
El exceso de Na + , carbonatos y bicarbonatos presentes en el agua de riego incrementan el pH, la conductividad eléctrica (CE) y el porcentaje de sodio intercambiable (PSI), afectando el crecimiento de los cultivos.
A. MUGUIRO, C. ÁLVAREZ, F. BABINEC, R. MARANO   +3 more
doaj   +1 more source